Nweke, Ekene Emmanuel2017-09-272017-09-272017Nweke, Ekene Emmanuel (2017) Discovery of pancreatic cancer biomarker(s) using focused pathway analyses, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/23156>http://hdl.handle.net/10539/23156A Thesis submitted to the Faculty of Health Sciences, University of Witwatersrand, in fulfilment of the requirements for the degree of Doctor of philosophy. Johannesburg, 2017.Pancreatic cancer (PDAC) is a deadly type of cancer with almost an equal amount of new cases and deaths observed yearly. It accounts for about 7% of cancer related deaths worldwide with less than 5% of PDAC patients living up to 5 years. The lack of specific and sensitive diagnostic tests is strongly responsible for this poor statistic. The discovery of differentially expressed genes and proteins associated with PDAC is crucial to elucidating this condition and may lead to biomarker finding and further understanding of the disease. This in turn may lead to improved diagnostic tests for early diagnosis. The aim of this study was to identify novel potential biomarkers for PDAC. [No abstract provided. Information taken from summary]Online resource (xvii, 130 leaves)enPancreatic Diseases--diagnosisPancreatic NeoplasmsThesis