Shalekoff., Sharon.2019-03-222019-03-222003-07-15https://hdl.handle.net/10539/26617A thesis submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg For the Degree of Doctor of Philosophy in Medicine Johannesburg, 2003The chemokine receptors, CXCR4 and CCR5, are the major coreceptors for HIV-1 entry into CD4+ cells. In addition, they mediate chemotaxis in response to stromal cell-derived factor (SDF- la) (CXCR4) and macrophage inflammatory protein (MlP)-la, MIP-ip and regulated on activation, normal T cell expressed and secreted (RANTES) (CCR5). Therefore, cell surface expression of these receptors has important implications for the study of the pathogenesis of HIV disease, in terms of viral entry as well as cellular trafficking.enHIV-1Receptors, CXCR4Receptors, CCR5Receptors, CCR5Receptors, ChemokineThesis