Coetzee, Kirstin Janine2015-09-022015-09-022015http://hdl.handle.net/10539/18401Endoscopic Retrograde Cholangiopancreatography (ERCP) with bile and pancreatic duct brushings is a first-line diagnostic investigation in patients with pancreatic carcinoma and cholangiocarcinoma presenting with obstructive jaundice. Biliary brushing cytology has a high specificity approaching 100%, but sensitivity is only modest, with reported ranges in the literature of 42-88%.enThesis