Nhiwatiwa, Melody2014-02-132014-02-132014-02-13http://hdl.handle.net10539/13747A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfillment of the requirements for the degree of Master of Science in Medicine in Pharmacotherapy, Johannesburg, 2011Long term antiretroviral therapy (ART) use is known to cause various toxic adverse effects in patients. Hepato-toxicity is one of the most significant adverse effects which have been associated with all antiretroviral therapy drugs in South Africa and worldwide.enAntiretroviral Therapy, Highly ActiveDrug-Induced Liver InjuryLiver--drug effectsThesis