Rabinowitz, David2019-10-152019-10-151962https://hdl.handle.net/10539/28270Thesis presented for the degree of Doctor of MedicineTh.e energy mechanisms present in skeletal muscle have been extensively studied by biochemists using in vitro system s. (Per example see 1, 2, 3). By contrast, attempts to quantify skeletal muscle metabolism in situ — and thereby to establish the pattern of energy metabolism in use, rather than that which is potentially available — have been relatively Infrequent. While the human forearm is undoubtedly composed of a number of different tissues, by far its greatest bulk is skeletal muscle. Correctly used, it provides a readily accessible tool for the appraisal of skeletal muscle metabolism in situ. The material to be presented in this dissertation describes the results of studies of basal metabolism of skeletal muscle and adipose tissue in the human forearm in control subjects and in individuals in whom metabolism was altered either by obesity or by endocrine disease. The studies are based upon the application of, and strict adherence to the principle outline by Pick in 1870 (4).enThesis