Lamparelli, Rosario D. V.2018-07-062018-07-061990https://hdl.handle.net/10539/24785A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg in fulfilment of the Degree of Master of Science in the branch of MedicineThe guinea pig clears circulating tissue ferritin in a manner different from other mammals. Previous work in man and in rats has shown that injected tissue ferritin is removed from the plasma predominantly by the liver; however, in the guinea pig it is cleared predominantly by red cell precursors and furthermore, the ferritin iron is utilised directly for haem synthesis. During pregnancy, the foeto-placental complex also has a high requirement for iron.enFerritinsBiological TransportPlacentaSwineThesis