Andrew K. MayHeather SeymourHarriet EtheredgeHeather MaherMarta C. NunesShabirA.MadhiSimisoM. SokhelaW. D. FrancoisVenterNeil MartinsonFirdaus NabeemeeahCheryl CohenJocelyn MoyesSibongile WalazaStefano TempiaJackie KleynhansAnne von GottbergJeremy NelHalima DawoodEbrahim VariavaStephen TollmanKathleen KahnKobusHerbstEmilyB.WongCarolineT.TiemessenAlex van BlydensteinLyle MurrayMichelle VenterJune FabianMiche´le Ramsay2024-04-052024-04-052022-10-06https://hdl.handle.net/10539/38333However, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa’s response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA—a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. *rough this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. *is project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities.enArticle