De Almeida, Maria, Rosario2018-10-022018-10-021992https://hdl.handle.net/10539/25712A dissertation submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg For the degree of Master of Science in MedicineChloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptical parasites, and this is thought to be the basis of their resistance ( Fitch, 1970 ). Martin et. al ( 1987 ), recently demonstrated that in the presence of verapamil, a calcium channel blocker, chloroquine-resistant P falciparum becomes chloroquine-sensitive, with an increase in the chloroquine accumulation.The mechanism of such reversal has yet to be elucidatedenhemozoinPlasmodiumPlasmodium falciparumATP-Binding Cassette, Sub-Family B, Member 1Thesis