Siegenberg, David2018-07-032018-07-031989-06https://hdl.handle.net/10539/24699A dissertation submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg for the Degree of Master of Science in MedicineThe effects of various manoeuvres on the handling of 59 Fe labelled heat damaged red cells (59Fe HDRC) by the reticuloendothelial system were studied in rats. The study demonstrated that prior saturation of transferrin with oral carbonyl iron had little effect on splenic release of 59Fe but markedly inhibited hepatic release . Splenic release was , however, inhibited by the prior administration of unlabelled HDRC.enThesis