Durig, Thomas.2018-11-202018-11-201991-08https://hdl.handle.net/10539/26090A Dissertation Submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg for the Degree of Master of Pharmacy. Johannesburg, August 1991In this dissertation physicochemical properties of the Bs vitamer, pyridoxal hydrochloride (PL HC1), are investigated with the aim of generating the necessary profile for the rational development of a stable, safe and effective formulation containing this drug. Recent research suggests that administration of PL HC1 may be particularly effective in raising the depleted intracellular pyridoxal phosphate levels found in many asthmatics treated with theophylline. The solubility characteristics of PL HC1 suggest that its absorption and bioavailability should not be problematicenPyridoxalChemical PhenomenaTheophyllineThesis