Brooksbank, Richard L2016-11-072016-11-071993Brooksbank, Richard L. (1993) The role of the conserved ASP443 and ASP498 residues in the polymerase and RNase H activities of HIV-1 reverse transcriptase, University of the Witwatersrand, Johannesburg, <http://wiredspace.wits.ac.za/handle/10539/21434>http://hdl.handle.net/10539/21434Submiltted in fulfillment of the requirements for the degree of Master of Science in the faculty of Science, University of the Witwatersrand, Johannesburg • Johannesburg 1993.The roles of the highly conserved aspartic acid residues found at positions 443 and 498 within the RNase H domain of Human Immunodeficiency Virus type-1 reverse transcription were investigated by the defined substitution of these residues using site-directed mutagenesis. [Abbreviated Abstract. Open document to view full version]Online resource (141 leaves)enHIV (Viruses)--EnzymesHIV (Viruses)--ResearchAIDS (Disease)--Research.Medical virologyMedical microbiologyThesis