Baynes, Roy, Dennis2018-06-272018-06-271987https://hdl.handle.net/10539/24673A thesis submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, for the Degree of Doctors of Philosophy.This thesis evaluates several aspects of iron metabolism in the setting of infection, inflammation and neoplasia. The work is divided into three major sections. The first investigate the changes in iron metabolism that occur as part of the acute phase response to infection, inflammation and neoplasia. The second section evaluates the normal and pathological biology of the iron-binding glycoprotein lactoferrin. IN the third section the iron transport protein transferrin is investigated in relation to its interaction with the macrophage, a cultured malignant hepatoma cell and a cultured malignant ovarian cell.enIron Metabolism DisordersInflammationNeoplasmsC-Reactive ProteinThesis