Danielle GiovencoAudrey PettiforKimberly A PowersLisa Hightow-WeidmanBrian W PenceJessie K EdwardsKatherine GillJennifer F MortonAriane van der StratenConnie CelumLinda-Gail Bekker2024-04-012024-04-012022-04https://hdl.handle.net/10539/38256Effective strategies to support PrEP adherence among adolescent girls and young women (AGYW) are needed. We examined PrEP use disclosure and its effect on adherence among 200 AGYW ages 16-25 initiating PrEP in South Africa to help inform these strategies. We estimated the relative prevalence of high adherence (intracellular tenofovir-diphosphate concentration ≥ 700 fmol/punch) 3- and 6-months after PrEP initiation among those who disclosed vs. did not disclose their PrEP use, both overall and by age. Most AGYW disclosed to a parent (58%), partner (58%), or friend (81%) by month 6. We did not observe a strong effect of disclosure on adherence overall; however, among younger AGYW (≤ 18 years), those who disclosed to a parent were 6.8 times as likely to have high adherence at month 6 than those who did not (95% CI 1.02, 45.56). More work is needed to understand parents' roles as allies and identify ways peers and partners can motivate PrEP use for AGYW.enAdolescent girls and young women; Disclosure; HIV prevention; PrEP; Pre-exposure prophylaxis.Article