Millen, Aletta M.E.Gunter, SulèMichel, Frederic S.Fourie, SerenaSingh, MikayraLe Roux, ReginaManilall, AshmeethaMokotedi, Lebogang.PalesaMillen, Aletta M.E.2022-01-102022-01-102022-01-13Dataset from:The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis Sulè Gunter, Frederic S. Michel, Serena Fourie, Mikayra Singh, Regina Le Roux, Ashmeetha Manilall, Lebogang Mokotedi, Aletta M.E. Millen Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.( in Press)https://hdl.handle.net/10539/32604http://doi.org/10.54223/uniwitwatersrand-10539-32604The dataset consists of 129 datapoints. The data is taken across two-time points. The dataset comprises two components. A subset from a previous study (Le Roux R, Mokotedi L, Fourie S, Manilall A, Gunter S, Millen AME. TNF-α inhibitors reduce inflammation-induced concentric remodelling but not diastolic dysfunction in collagen-induced arthritis. Clin Exp Rheumatol. 2021. Epub Jan 2021.) and additional data were collected for this study. The codebook details 58 variables, with ranges, definitions and protocols. However, only complete data is available for only 7 variables: number, group, sex, time in weeks, bodyweight in grams, Systolic and diastolic blood pressure. Rats were randomly divided into the control (n=24, 9 females and 15 males), CIA (n=24, 12 females and 12 males) and CIA+etanercept (n=16, 8 females and 8 males) groups. Systemic inflammation was induced in the CIA and CIA+etanercept groups using bovine type II collagen dissolved in incomplete Freund’s adjuvant, as previously reported (Le Roux et al., 2021). Upon the first signs of inflammation, approximately 3-4 weeks after CIA was first induced. Rats in the CIA+etanercept group received intraperitoneal injections of etanercept (Enbrel) and a 10 mg/kg dose of TNF-α inhibitor (Roche, Basel, Switzerland) every three days for six weeks. The data reports on the experiment and its resulting markers of inflammation and responses in mesenteric arteries.enAnimals in this study were kept at the Wits Research Animal Facility at the University of the Witwatersrand Faculty of Health Sciences. Although every effort was made to carefully control experimental conditions, unknown external factors may still impact on the reproducibility of the study. The authors can therefore not guarantee that results will be identically reproduced in a different laboratory setting. This data is open however we do request that should you wish to make use of the data published by this study, or if you should need further data relating to the larger study please contact the corresponding author (Dr Sulè Gunter) at sule.gunter@wits.ac.za.Arthritis, Rheumatoid / physiopathologyVascular Stiffness / physiology*Dataset