Naran, Nitien, Hira.2018-05-172018-05-171996-03https://hdl.handle.net/10539/24488A dissertation submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg, for the Degree of Master of ScienceFamilial hypercholesterolaemia IIa (F. H. IIA) is a congenital disorder characterized by a raised plasma level of low density lipoprotein (LDL). Platelets in this condition have been found to be hypersensitive to aggregating agents and to produce increased amounts of thromboxane A2.These modifications of platelet function and biochemistry may play an important role in the occurrence of premature atherosclerosis and myocardial infarction in adolescence and young adults.In Vitro TechniquesBlood PlateletsPlatelets Function testsHypercholesterolemiaLipoproteins, LDLAtherosclerosisThesis