Peter, Amanda, Clare2018-06-082018-06-082002https://hdl.handle.net/10539/24633A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Science ( Medicine ) in pharmaceutical affairs JohannesburgSouth Africa has the highest number of registered medicine containing meprobamate in combination analgesics and is the only country that markets a combination that includes paracetamol, caffeine and codeine. In November 1998 the \medicine Control Council issued a circular (11/98) to the pharmaceutical industry requesting evidence that meprobamate contributes meaningfully to the therapeutic effect in combination analgesics and asked for comment on the risk-benefit ratioeneconomic factorprofitMeprobamateAnalgesicsThesis