E-learning as an innovative platform for medical doctors in South Africa Student: Terence Pillay Supervisor: Laurence Beder A research report submitted to the Faculty of Commerce, Law and Management, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Management specialising in Strategic Marketing Johannesburg, 2020 i ABSTRACT E-learning could be an innovative continued medical education platform for medical doctors in South Africa, especially now with the COVID-19 pandemic and its effects on physical contact between pharmaceutical companies’ representatives and doctors. This study aimed to determine and develop a more effective way to reach and provide accurate, credible education for all doctors using an e-learning platform as an alternative to representative visits. This research involved a quantitative study, deploying a survey to a sample of 456 doctors in South Africa via an online platform. The results arising from the analyses to prove the three hypotheses were statistically significant, and all were accepted. In summary doctors in South Africa valued their relationships with medical representatives, but simultaneously questioned the credibility of the education received from the representatives. Many doctors accessed the internet for their own education as one of their channels of education. In view of the research findings, an innovative e-learning platform is proposed to deliver continued medical education to all doctors and to allow for best practices sharing across the medical fraternity in South Africa. ii DECLARATION I, Terence Pillay, declare that this research report is my own work except as indicated in the references and acknowledgments. It is submitted in partial fulfilment of the requirements for the degree of Master of Management in Strategic Marketing at the University of the Witwatersrand, Johannesburg. It has not been submitted before for any degree in this or any other university. T. Pillay __________________ Terence Pillay Signed at Ascot, Berkshire, United Kingdom On the 29th day of August 2020 iii DEDICATION This report is dedicated to Lena Pillay who never stopped motivating and reminding me of the journey I started and why I had to finish it. She allowed me to be me. Thank you for lending yourself to me and for being the spine as I wrote this chapter of our life. iv ACKNOWLEDGEMENTS My heartfelt and sincere appreciation goes to the following key instrumental people who made this research report a success:  Mr Laurence Beder, my supervisor. Your words of motivation, patience and coaching that we will get through, helped me to breathe a little more and press on;  My mum and dad for an indescribable gift. ‘Go for it, Dream Big!’ will always resonate with me;  Noah Liam Pillay and Gianna Cara Pillay who afforded me the time to focus on what needs to get done, ‘Oh the places we will go’; and  Zak Ahmed Baig for saying ‘YES’. v TABLE OF CONTENTS ABSTRACT ...................................................................................... I DECLARATION ............................................................................... II DEDICATION ................................................................................. III ACKNOWLEDGEMENTS .............................................................. IV TABLE OF CONTENTS ................................................................. V LIST OF TABLES ........................................................................ VIII LIST OF FIGURES ......................................................................... X CHAPTER 1: INTRODUCTION ....................................................... 1 1.1 PURPOSE OF THE STUDY ............................................................................ 1 1.2 THEORETICAL BACKGROUND TO THE STUDY ................................................. 1 1.2.1 DIFFUSION OF INNOVATIONS MODEL ........................................................................ 1 1.2.2 TECHNOLOGY READINESS INDEX ............................................................................. 2 1.3 CONTEXT OF THE STUDY ............................................................................. 2 1.4 PROBLEM STATEMENT ................................................................................ 6 1.4.1 SUB-PROBLEM 1 .................................................................................................... 6 1.4.2 SUB-PROBLEM 2 .................................................................................................... 6 1.5 SIGNIFICANCE OF THE STUDY ...................................................................... 7 1.6 DEFINITION OF TERMS ................................................................................ 8 1.7 CONTRIBUTION OF THE STUDY ..................................................................... 9 CHAPTER 2: LITERATURE REVIEW ........................................... 10 2.1 INTRODUCTION ........................................................................................ 10 2.2 DIFFUSION OF INNOVATIONS MODEL ........................................................... 10 2.3 TECHNOLOGY READINESS INDEX ............................................................... 14 2.4 DETAILING TO HEALTHCARE PROFESSIONALS .............................................. 22 2.5 BARRIERS TO INNOVATIONS ...................................................................... 27 2.5.1 RELATIVE ADVANTAGE .......................................................................................... 29 2.5.2 COMPATIBILITY .................................................................................................... 29 2.5.3 COMPLEXITY ........................................................................................................ 30 2.5.4 TRIAL-ABILITY ...................................................................................................... 30 2.5.6 OBSERVABILITY ................................................................................................... 30 2.6 DETAILING REPRESENTATIVES ADDING VALUE TO CME OF DOCTORS ............ 32 vi 2.7 ACADEMIC DETAILING TO IMPROVE CLINICAL DECISION-MAKING .................... 39 2.8 E-LEARNING AS A SOURCE OF DETAILING AND EDUCATING DOCTORS ............. 45 2.9 E-LEARNING AS A SELF-DIRECTED EDUCATIONAL TOOL FOR DOCTORS .......... 53 2.10 EFFECTS OF THE COVID-19 PANDEMIC ..................................................... 56 2.11 CONCEPTUAL MODEL OF ANALYSIS ............................................................ 61 2.11.1 HYPOTHESIS 1 ..................................................................................................... 62 2.11.2 HYPOTHESIS 2 ..................................................................................................... 62 2.11.3 HYPOTHESIS 3 ..................................................................................................... 62 2.12 CONCLUSION OF LITERATURE REVIEW ........................................................ 62 CHAPTER 3: RESEARCH METHODOLOGY ............................... 66 3.1 INTRODUCTION ........................................................................................ 66 3.2 RESEARCH METHODOLOGY ....................................................................... 66 3.3 RESEARCH APPROACH / PARADIGM ............................................................ 66 3.4 RESEARCH DESIGN .................................................................................. 69 3.5 POPULATION AND SAMPLE......................................................................... 70 3.5.1 POPULATION ........................................................................................................ 70 3.5.2 SAMPLE AND SAMPLING METHOD ........................................................................... 70 3.6 THE RESEARCH INSTRUMENT .................................................................... 70 3.7 PROCEDURE FOR DATA COLLECTION .......................................................... 72 3.8 DATA ANALYSIS ........................................................................................ 72 3.9 VALIDITY AND RELIABILITY ......................................................................... 73 3.9.1 EXTERNAL VALIDITY ............................................................................................. 74 3.9.2 INTERNAL VALIDITY ............................................................................................... 74 3.9.3 RELIABILITY ......................................................................................................... 75 3.10 LIMITATIONS OF THE STUDY ....................................................................... 76 CHAPTER 4: PRESENTATION OF RESULTS ............................. 77 4.1 INTRODUCTION ........................................................................................ 77 4.2 DEMOGRAPHIC CHARACTERISTICS OF THE RESPONDENTS ........................... 77 4.2.1 GENDER .............................................................................................................. 77 4.2.2 HOME LANGUAGE ................................................................................................. 78 4.2.3 PROVINCE OF PRACTICE ....................................................................................... 79 4.2.4 PRACTICE SECTOR ............................................................................................... 80 4.3 DESCRIPTIVE STATISTICS .......................................................................... 81 4.3.1 ATTITUDE TOWARDS DETAILING REPRESENTATIVES ................................................ 81 4.3.2 SOURCE OF INFORMATION FOR DOCTORS .............................................................. 83 4.3.3 E-LEARNING BEHAVIOUR OF DOCTORS .................................................................. 84 4.4 FACTOR ANALYSIS .................................................................................... 85 4.5 RELIABILITY ANALYSIS .............................................................................. 87 4.6 TESTING FOR DIFFERENCES BETWEEN GROUPS .......................................... 88 4.6.1 DOCTORS’ GENDER .............................................................................................. 88 4.6.2 DOCTORS’ PRACTICE SECTOR ............................................................................... 90 4.7 CORRELATION ANALYSIS ........................................................................... 90 vii 4.8 MULTIPLE REGRESSION ............................................................................ 94 4.8.1 PREDICTION LEVEL OF EDUCATION ........................................................................ 94 CHAPTER 5: DISCUSSION OF RESULTS ................................... 95 5.1 INTRODUCTION ........................................................................................ 95 5.2 DEMOGRAPHIC PROFILE OF RESPONDENTS ................................................ 95 5.3 HYPOTHESIS TESTING .............................................................................. 95 5.3.1 HYPOTHESIS 1 ..................................................................................................... 96 5.3.2 HYPOTHESIS 2 ..................................................................................................... 97 5.3.3 HYPOTHESIS 3 ..................................................................................................... 98 5.4 CONCLUSION ......................................................................................... 100 CHAPTER 6: CONCLUSIONS AND RECOMMENDATIONS ...... 102 6.1 INTRODUCTION ...................................................................................... 102 6.2 CONCLUSIONS OF THE STUDY ................................................................. 102 6.2.1 E-LEARNING PLATFORMS DELIVER ACCESSIBLE, CREDIBLE EDUCATIONAL CONTENT TO ALL DOCTORS .................................................................................................... 102 6.2.2 FACE-TO-FACE DETAILING CONTRIBUTES TO CREDIBLE VALUABLE EDUCATION TO DETAILED DOCTORS IN THEIR CLINICAL DECISION-MAKING PROCESS ...................... 103 6.2.3 THE POSITIVE RELATIONSHIP BETWEEN FACE-TO-FACE DETAILING AND E-LEARNING PLATFORMS CONTRIBUTE TO THE EDUCATION OF DOCTORS .................................. 104 6.3 IMPLICATIONS OF THE STUDY ................................................................... 105 6.3.1 THEORETICAL IMPLICATIONS ............................................................................... 105 6.3.2 MANAGERIAL IMPLICATIONS ................................................................................ 106 6.3.3 COVID-19 IMPLICATIONS ................................................................................... 106 6.4 RECOMMENDATIONS FOR FUTURE E-LEARNING ......................................... 107 6.4 SUGGESTIONS FOR FUTURE RESEARCH.................................................... 108 REFERENCES ............................................................................ 109 APPENDIX A – RESEARCH INSTRUMENT ............................... 118 APPENDIX B – RESEARCH COVER LETTER ........................... 122 APPENDIX C – FACTOR ANALYSIS AND RELIABILITY .......... 124 APPENDIX D – CORRELATION ANALYSIS AND MULTIPLE REGRESSION ANALYSIS .......................................................... 126 viii LIST OF TABLES Table 1: Gender distribution ............................................................................. 77 Table 2: Home language .................................................................................. 78 Table 3: Province of practice ............................................................................ 80 Table 4: Practice sector ................................................................................... 80 Table 5: Agreement scale: Attitude towards detailing representatives ............. 82 Table 6: Mean and standard deviation: Attitude towards detailing representatives ......................................................................................................................... 82 Table 7: Agreement scale: Source of information ............................................ 83 Table 8: Mean and standard deviation: Source of information ......................... 84 Table 9: Agreement scale: E-learning behaviour ............................................. 84 Table 10: Mean and standard deviation: E-learning behaviour ........................ 85 Table 11: KMO and Bartlett test results ........................................................... 86 Table 12: Factor analysis results ...................................................................... 87 Table 13: Cronbach’s alpha values .................................................................. 88 Table 14: Gender t-test results ......................................................................... 90 Table 15: Sector t-test results .......................................................................... 90 Table 16: Correlation analysis: Attitude towards detailing representatives ...... 92 Table 17: Correlation analysis: E-learning behaviour ....................................... 93 Table 18: Correlation analysis: Source of information ...................................... 93 Table 19: Multiple regression analysis: Education ........................................... 94 ix Table 20: Multiple regression coefficient analysis ............................................ 94 Table 21: Correlation analysis for source of information .................................. 96 Table 22: Attitude towards doctor detailing representatives ............................. 97 Table 23: Multiple regressions coefficient analysis .......................................... 99 x LIST OF FIGURES Figure 1: Triangle and pyramid models of services marketing 18 Figure 2: HHK’s multi-faceted paths 32 Figure 3: Prescribing behaviour change before and after academic detailing 41 Figure 4: Study periods and academic detailing 43 Figure 5: Effect of academic detailing on antibiotics prescriptions 45 Figure 6: Selected e-detailing approaches 48 Figure 7: Benefits and challenges of e-detailing in Europe 49 Figure 8: Spectrum of communication options 50 Figure 9: Key messages in the product life cycle 51 Figure 10: Motivations for physicians searching on internet 55 Figure 11: Factors important to physicians in accessing online CMEs 56 Figure 12: Conceptual model of analysis 62 Figure 13: Gender distribution 78 Figure 14: Home language 79 Figure 15: Practice sector 81 1 CHAPTER 1: INTRODUCTION 1.1 Purpose of the study The purpose of this research was to establish whether e-learning could be an innovative continued medical education platform for medical doctors in South Africa. The e-learning platform was examined to establish its effect on doctors’ medical education. In view of the COVID-19 pandemic in 2020, this research also investigated its impact thus far on doctors’ e-learning. 1.2 Theoretical background to the study This study has theoretical roots in two primary domains (Singh, 2014). 1.2.1 Diffusion of innovations model This model by Rogers (2003) explains how an innovation spreads via communication channels to members in a social system, which resonates with the medical profession. The origins of this model are attributed to the behavioural sciences. The diffusion of innovations model looks at four elements, which are innovation, communication channels, time, and social systems. Rogers (2003) defined an innovation as an idea, practice, or project that an individual is exposed to for the first time. The innovation could have existed for a long time, but the first time experience for the user makes it an innovation for that person. Diffusion is how the adoption of the innovation takes place. Communication channels are segmented into localite and cosmopolite channels that communicate between an individual of a social system and outside resources. Time is a critical factor in the innovation – diffusion process, as it puts the innovation in a category and shows its rate of adoption. Rogers (2003) defined the social system as set of interrelated units trying to solve a common problem and accomplish a goal. This is what doctors in the medical professional do daily, 2 working cross-functionally with different faculties to solve a common medical problem. 1.2.2 Technology readiness index The conceptual framework for classifying innovations comprises (a) continuous innovations, (b) dynamically continuous innovations, and (c) discontinuous innovations (Robertson, 1967). A continuous innovation has the least interruption to a pattern. This can be an alteration to a product and not the establishment of new product. A dynamically continuous innovation has more disruption than a continuous innovation, although generally not altering established patterns. It may involve the creation of a new product or the alteration of an existing product. A discontinuous innovation involves an establishment of a new product and the establishment of new behaviour patterns. The e-learning platform to educate doctors will be a discontinuous innovation as this will be a new educational platform to change behaviour patterns of doctors to embrace and be educated online. The technology readiness index was adopted in this research to look at the readiness of doctors to adopt the new e-learning platform (Parasuraman & Colby, 2015). This platform caters for the gaps in their medical education and affords doctors an opportunity to be educated at a convenient time and in a comfortable situation. 1.3 Context of the study The formal educational requirement for doctors to qualify takes an average of six to eight years after completing their school education. To keep up-to-date on the latest clinical findings and education thereafter, they attend conferences, advisory boards, and focus group meetings. The invitations to these meetings are done through targeting and selection by pharmaceutical companies. Doctors are identified by the potential of their prescription habits and influence on the market share. Medical representatives are then trained and educated to call on these doctors and detail to them the latest clinical advancements in medicine and 3 product benefits. The aim of the representative is to get doctors to script the company’s product more frequently (Soumerai & Avorn, 1990). Doctors that are not visited by representatives must access other means of educational sources. Some doctors do not have the time to see medical representatives due to their busy schedules, however still need to fill the gap in their education and attain continued professional development points. The manner in which pharmaceutical companies establish relationships and call on doctors is called to question by many doctors who see this as an unethical practice and refuse to see representatives (Gonul, Carter, Petrova, & Srinivasan, 2001). Doctors need to be at forefront of the latest discoveries in medicine to prescribe their patients with the safest and most effective drugs thus ensuring an efficient treatment plan. In the 1920s, many studies looked at the education of healthcare professionals and including modern science into medical faculties in universities. These teaching schools looked at equipping health professionals with knowledge that would double the life span of the 20th century (Frenk et al., 2010). This created a wave of medical teaching universities to be opened in United States (US) and Canada, which filtered into Europe with the vision of sharing advancements in medical science and discoveries equitably. In the twenty-first century, this has still not been achieved and there are major gaps in sharing of information and knowledge. Medical science is advancing with clinical breakthroughs, and new diseases and health conditions emerging. The migration of people from one geographical location to the next brings with it complexities in healthcare treatment throughout the world. Worldwide healthcare systems are being overburdened with the shortage of staff. The professional education of healthcare workers has not kept pace with the changing environment. The divide in wealth among countries, and the migration of doctors from one region to another has increased the divide of transferring education, knowledge, skills, and new reforms in medicine evenly (Frenk et al., 2010). 4 Health is all about people and it involves one set of professionals providing a community and societal service to another set of unhealthy individuals. The relationship between doctor and patient is based on ethical standards, trust, and the educational competence of the medical professional. There is a multifaceted channel of events with the aim of delivering high quality care; the medical doctor needs ongoing education on the latest trends in medicine, so that the patient gets the best treatment. Uniform education for all medical doctors should deliver effective clinical practice to patients. This is not happening in the healthcare industry. Pharmaceutical companies are targeting doctors according to their scripting habits and using script data from data mining companies like IMS Health (Fugh-Berman & Ahari, 2007) to target doctors and drive the company’s market share. Doctors are being targeted by pharmaceutical representatives according to the script share data, from which marketing and sales strategies are put into place with the aim of driving profit from sales. On average, a representative will see between six and eight doctors per day, spending between five and eight minutes detailing doctors. The line-up of the detail call is usually two products, with a third product as a leave behind reminder (Soumerai & Avorn, 1990). The medical doctors at the top of the healthcare pyramid become the key opinion leaders on a specific therapeutic area and are given preferential treatment to attend conferences and invited to be keynote speakers. Medical advancements remain within the elite targeted doctors and key opinion leaders. Many doctors, who are not the highest prescribers in a category, are not included in the invitations to CME meetings (Fugh-Berman & Ahari, 2007). Many medical doctors are migrating to the cities to generate a higher income and thus become high script generators. Pharmaceutical companies use the Pareto principle and target doctors accordingly, thus decreasing their resources for reaching doctors in rural and country settings. Some representatives make a country visit once a month to target these doctors, and are fortunate doctors is in their practice on that day. This segmented targeting of doctors is creating a further gap in continued professional development of doctors not targeted by pharmaceutical companies. 5 As time proceeds, the lack of CME increases and the new and latest advancements in medical science does not reach doctors. This has been a major issue from as early as 1910, as mentioned in the Flexner report to the Carnegie Institute on medical education (Flexner, 2002). In the spirit of Abraham Flexner, the 2010 report had a similar idea of reform in medical education, that the report would generate some excitement on the reform of innovation in education for graduate and undergraduate medical professionals. Three US reports have had powerful effects on the professional health education in North US and this has spread to the rest of the world: the Flexner report of 1910, the Welch-Rose report of 1915, and the Goldmark report of 1923 (Frenk et al., 2010). All these reports called for major instructional reforms to allow modern medical sciences into the core curriculum, to link education to research, and to base professional education in universities. To cater for the gap in doctors’ continued medical education (CME) and to gain their continued professional development points, the e-learning platform could bring about a reform in their medical education. This innovation would give access to education irrespective of them being seen by medical representatives or attending CME activities. This would remove the discrepancy by pharmaceutical companies of only educating detailed doctors, and allow doctors the opportunity to manage their time effectively and avoid unethical business practices, thus focussing on the science of medicine and the best treatment options for patients. In view of the COVID-19 pandemic in 2020, this research considered its effect on detailing representative visits, and made a recommendation on curbing the impact of COVID-19 on doctors’ e-learning. Before the 2010 Flexner report, there were numerous developments on the future of education of medical doctors and health professionals on a local and international level. This gave rise to four sets of reports stressing the importance of medical reforms in education driven by the Millennium Development Goals (MDGs). The main objectives of these reports called for more competency-based programs, the sharing of best practices, and finally IT led, empowered learning. These reports recommended an increased investment in education and training, 6 sharing of resources, and a global interdependent world of health professionals (Frenk et al., 2010). In the education of doctors, the following constructs were critical in this research:  E-learning;  Innovation;  Detailing;  Technology readiness;  Continued professional development;  CME; and  Key opinion leaders. 1.4 Problem statement There is a need for CME of all doctors on clinical and product knowledge in the pharmaceutical industry (Soumerai & Avorn, 1990). The main problem is to determine and develop a more effective way to reach and provide accurate, credible education for all doctors using an e-learning platform as an alternative to representative detailing visits. 1.4.1 Sub-problem 1 To determine whether there is a preference by medical doctors to utilise visiting doctor detailing representatives for their education or an e-learning platform. 1.4.2 Sub-problem 2 To determine if there is a positive correlation between the impact of e-learning behaviour on doctors education and clinical decision-making. 7 1.5 Significance of the study The objectives of the study included the following:  The main objective of the study was to emphasise the critical role that an innovation in e-learning contributes to the CME of medical doctors (Frenk et al., 2010). Medical institutions face the challenge of educating doctors for tomorrow due to less teaching time available at medical schools. It is also evident that there is a gradual movement from classroom face-to- face teaching to a more self-directed learning approach (Ruiz, Mintzer, & Leipzig, 2006). In view of this, e-learning provides an innovative solution to their CME.  The second objective of this study was to propose an innovative e- learning platform that doctors throughout the world can log into in the comfort of their home and at their chosen time to continue their ongoing education. This study looked at the evidence of the effectiveness of e-learning in getting a key clinical message across to doctors, and contributing to their education on scripting the safest and most effective drug for their patients. The way learning is delivered to doctors is the major advantage of e-learning, with content being available in real time, as new clinical findings are discovered, content is standardised and approved by medical associations, content is easily distributed, and accountability for learning rests with doctors (Ruiz et al., 2006). E-learning frees up time for doctors to concentrate on their patients and steer them clear of any unethical behaviour with pharmaceutical companies (Fugh- Berman, & Ahari, 2007). The aims of the study were evaluated and researched through extensive literature review comparing the CME among medical doctors and concluded with the proposal of an innovative CME e-learning platform for doctors. 8 1.6 Definition of terms An understanding of the following terms is essential in understanding the research:  Detailing: Forms part of strategic medical marketing and involves educating medical doctors using trained medical representatives as part of the broader marketing mix used by pharmaceutical companies. The representatives do personal selling to doctors using detailing aids that are paper based, drop off samples, literature, and patient information (Lilien, Rao, & Kalish, 1981).  E-detailing: Uses an electronic device such as a personal digital assistant, tablets, laptops, and podcasts (Bernewitz, 2001).  Detailed doctors: Doctors visited by representatives to provide education on the efficacy of a product (Zipkin, & Steinman, 2005).  Non-detailed doctors: Doctors not visited by a representative (Zipkin, & Steinman, 2005).  E-learning: - As defined by the American Society of Training and Development, learning that takes place through a wide set of applications and processes such as web-based platform learning, computer-based learning, virtual classrooms, and digital collaboration (Derouin, Fritzsche, & Salas, 2005).  Key opinion leader:– An academic, highly esteemed by colleagues in their profession, at the forefront of clinical research, and a thought leader in their profession who is called upon by pharmaceutical companies to deliver therapeutic area education and is a key influencer in getting a clinical message across (Soumerai & Avorn, 1990).  Innovation: An idea, practice or project that is seen as new by the individual (Rogers, Medina, Rivera, & Wiley, 2005). 9  Diffusion: A process in which an innovation spreads through certain communication channels over time (Rogers et al., 2005).  Communication channel: An avenue or platform through which information is shared to gain a common understanding of an idea or concept, or education of the target group (Rogers et al., 2005).  Continued professional development: An ongoing educational process by which medical doctors keep up-to-date on latest research, clinical findings, therapeutic area knowledge, and trends to deliver the best practice to their patients (Graham et al., 2006).  CME: An ongoing set of planned activities that medical doctors engage in to keep their knowledge up-to-date on the latest medical science. This can take the form of journals, conferences, and round table discussions (Graham et al., 2006). 1.7 Contribution of the study This study contributes to the efficacy of detailing and educating doctors on an innovative e-learning platform which enables pharmaceutical companies reaching all doctors in real time with the latest clinical findings and development of drugs so that patients’ basic right to the best medical practice is realised. Thought processes will be challenged, and policy changes will look at new innovative ways to allow doctors to gain their continued professional development points and have an interdependent world of exchanging best in class medical practices. This will allow for medical knowledge to be standardised, accredited, and acknowledged so there is consistency in the medical profession across markets. This research proposes an e-learning platform that will allow for the dissemination of medical knowledge to all doctors without any prejudices. Medical doctors will have access to CMEs in the comfort of their practices and homes without being side-lined by not being detailed to and not being invited by pharmaceutical companies to CME meetings. 10 CHAPTER 2: LITERATURE REVIEW 2.1 Introduction Chapter 2 consists of the literature review that supports the depth, understanding, and building blocks of this study. Literature sources were reviewed, compared, and critically analysed to form a firm base to the study of e-learning as an innovative educational platform for medical doctors. The subsections consist of the diffusion of innovations model, the technology readiness index, detailing to doctors, barriers that influence the adoption of innovations, e-learning, and finally a conceptual model is presented. 2.2 Diffusion of innovations model The origins of the diffusion model can be traced back to the field of agriculture in the 1950s. The model later lent itself to other sectors such as public health. Diffusion is a process by which an innovation, an idea, or project seen as new, or for the first time, begins to spread through communication channels in a social system (Rogers, 2004). Recently, approximately 5 000 studies on innovation range from seed corn and modern maths, to antibiotic drugs and AIDS prevention, have been made. The pioneers of the diffusion model were first seen in the study of two farming communities in the hybrid seed corn study in the state of Iowa (Ryan & Gross, 1943). This was the establishment of the shift for diffusion research. Ryan came over from Harvard and joined Iowa State University’s sociology department. He was very interested in the economics of agriculture, but then his vast reading of anthropological studies aroused his interest in understanding the non-economic factors that influenced the decisions that farmers made. He chose to study the diffusion and adoption of hybrid seed corn with the farmers there. He had a suspicion that sociological factors like the influence of the farmer’s neighbour played an important role in decision-making for the farmer. This decision either made the farmer adopt the seed corn or refuse to adopt (Ryan & Gross, 1943). 11 For Iowa State, the hybrid seed corn produced was a revolution in the corn production category. The corn produced gave rise to a genetically stronger crop that could withstand harsh environmental conditions and thus contributed to a higher increased yield of 20 per cent. At the time, mechanical combine harvesters were being introduced and the sturdy crop with strong stalks was better suited for harvesting by these machines, another advantage to be adopted. The droughts of 1934 and 1936 were not a challenge for the hybrid crop as it withstood these conditions as well. Such a revolutionary new hybrid crop would seem like good news among the farmers there and it was expected to diffuse at a fast rate among the farmers; instead, it was found that this diffusion process took 13 years (Ryan & Gross, 1943), with the first planting taking seven years. Of interest was the influence of neighbouring farmers in adopting the innovation. At the heart of the diffusion was the exchange of information on experiences and best practice sharing of the new idea. This gave rise to the term innovation. The diffusion model lent itself to other disciplines of study, such as medicine, nursing, and marketing, and Rogers was teaching it at University; therefore, the model itself started the diffusion process. The diffusion model has existed for over 60 years and the studies of diffusion have continued. The basic diffusion model of 1962 had some important additions to the model as outlined below:  Critical mass: Defined as reaching the higher volume of individuals that become the advocates of the innovation such that further diffusion takes place and becomes self-sustaining;  Focus on networks: As a means of further understanding of how a new idea spreads through interpersonal channels; and  Re-invention: A process by which an invention changes by its adopters as it evolves during the diffusion process. 12 The model has been reassessed with new emerging empirical data (Fitzgerald, Ferlie, Wood & Hawkins, 2002). Their findings were a result of two studies conducted in the United Kingdom healthcare system, which showed that there was no single, linear, one-fit route of the diffusion process. They looked at newly found evidence-based medical scientific discoveries, passive adopters of the diffusion process and the influence that different scenarios or contexts have on the diffusion process. The discovery of new clinical findings in medicine is classified as privileged information, which most of the time helps to break long- standing habits and behaviours among doctors. This context is knowledge- based, and the education is either new or problem solving information; these key drivers allowed the diffusion process to start (Williamson, 1992). Roger’s (1995) work focusses on whether need precedes the newfound knowledge or the other way around. However, these models provide limited interpretation of the knowledge in situations of ambiguity (Fitzgerald et al., 2002). In the medical profession, there is a hierarchy of how knowledge is cascaded. Knowledge transfer takes place by means of a pyramid structure or top-down approach. Among medical professionals, the science is argued, reasoned with the fraternity and networks, and clinical best practices are shared, thus allowing a slow rate of diffusion of the new knowledge. From this study, three key themes emerged. First was to validate the credibility of the evidence; discovery of new knowledge in the medical profession first needs to be accepted before it will be used in practice. The second, for an innovation to be adopted it requires the decision of active adopters, not passive. In this theme, there is interaction between actors and innovations, and between groups. The third theme looks at the interlocking characteristics of communities. These three themes all affect the diffusion process. The process of diffusion is not straightforward but very complex and full of uncertainty. Diffusion requires a network of interwoven relationships. In medical evidence, no direct or distinct connection with the discovery of the new science and the rate of diffusion existed. The high quality of evidence did not have an impact on the diffusion. 13 Diffusion in the healthcare system is not only affected by budget constraints but also political hierarchy in the system. As mentioned previously (Rogers, 1995), diffusion is not only complex and uncertain, it involves many interactions, which go beyond re-invention or translation, as in the actor-network theory (Latour, 1987). Users have their own interpretations and negotiate on what they thought to be credible evidence. This modification to suit their needs also assisted the diffusion process. In the healthcare sector, there is a very complex system of interactions between professors, physicians, doctors, nurses, and pharmacists. The knowledge transfer from one professional to the next can be very sticky and this affects the overall diffusion process. In this profession and the race for science and credibility, academics and politics go hand in hand, and this causes the complexity in knowledge transfer (Van de Ven, 1999) The healthcare sector has many interlocking relationships that affect the rate of diffusion as the study by Fitzgerald et al. (2002) found. The history, culture, and quality of relationships affect the rate of diffusion and this too evolves over time. The learning and change capacity also vary as per local settings, adaptations, and negotiations, which mean that diffusions cannot roll out readily. The study alludes to the point that there is no uniform pattern in the diffusion of an innovation, the diffusion process in multifaceted and depends on a myriad of characteristics. In the healthcare sector, the use of key opinion leaders is another critical pathway that affects the rate of diffusion of an innovation (Valente, 1999). Several criteria exist, by which key opinion leaders are chosen and selected, each with their own pro and cons. A key opinion leader is selected in five ways: (1) Key opinion leaders will select themselves; (2) Project teams and staff will select key opinion leaders; (3) Members in a community will recruit participants that are not leaders, these participants in turn will recruit new participants (Broadhead, Heckathorn, Grund, Stern, & Anthony, 1995); this was seen much in the AIDS project, where participants were comfortable in this approach; 14 (4) Individuals within a community selected other key people to be opinion leaders (Kelly et al., 1991); or (5) All community members are invited to nominate key opinion leaders (Lomas et al., 1991). Each of these methods has its own drawbacks. When selecting a key opinion leader, the trustworthiness and credibility of that person has a direct impact on the rate of adoption and diffusion. These leaders come to meetings to push their own agendas and very rarely have the community’s interests as their focal point. Being resolute on their agenda, they lack the expertise of knowing the needs of the adopters. The third approach is temporary in nature, and key ideas and behaviours are not communicated effectively; however, allowing community members to nominate leaders takes care of the main disadvantage. The fourth approach provides a pool of community leaders, the drawback being the method of selection and possible bias in the process. The fifth approach is similar to a democratic presidential election. The trustworthiness and credibility of the opinion leader is ensured through this method, as the people nominate the leader. This allows for a mix of leaders each with different skill sets and knowledge that permits a better intervention and dissemination of the knowledge as and when required in the diffusion process. The selected opinion leader can then be educated and trained in the intervention or knowledge, and paired up with a community leader. This is vital as it affects the rate of diffusion and adoption of the innovation within the community (Valente, 1999). 2.3 Technology readiness index The technology readiness index is a 36-item scale that was first published in 2000. Technology readiness as defined by Parasuraman and Colby (2015) is peoples’ ability to accept and use new technologies for accomplishing goals both at work and in their personal lives. As the years have passed, technology has found its place in every service category. The rise of the internet has seen an 15 exponential growth over the years, and the growth of mobile technology has been prolific, and is on the increase year-on-year (Brahima, 2013). Social media is another channel that has accelerated at a staggering rate – Facebook had 1 million subscribers worldwide in 2004, 350 million in 2009, and over 1 billion in 2012. While the areas of speed, capacity, connectivity, functionality, and the ease of use of current technologies is a focus, innovations are near discovery. Technology-triggered transformation is likely to continue accelerating (Parasuraman & Colby, 2015). With the rise of technology set to revolutionise services, managers need to be mindful of the complexity that arises from delivering innovative customer experiences and customers being receptive to those experiences. The customer needs to know how to interact and use the new technologies, and manage its content. If this is not done, it leads to frustration and poor user experience, which in turn affects the rate of adoption and the diffusion process negatively. Employees need to be minimally affected, which requires constant communication, education, and training in the areas of new technology, which in turn makes employees comfortable and confident about the new technology. If this is not addressed, then productivity and staff morale can decline. Understanding consumers’ readiness for technology adoption is critical in understanding their reactions (Parasuraman & Colby, 2015). The original technology readiness index had its roots in literature on adoption of new technologies and interactions between people and technology. Parasuraman (2000) mentions the work of Mick and Fournier (1998) who conducted research on people’s use, response, and reactions and identified eight different opposite states, for example freedom/enslavement, assimilation/isolation, and efficiency/inefficiency. Their findings meant that technology had both positive and negative feelings (Mick & Fournier, 1998). Many previous studies in the areas of interactive media, tele-shopping, and self- service technologies (SST), strengthened Parasuraman and Colby’s (2015) argument that relative dominance of positive and negative feelings about technology would be different across people and cause corresponding variations in people’s ability to embrace and employ new technologies. Similarly, other 16 studies (Davis, Baggozzi, & Warshaw, 1989) found specific consumer beliefs and motivations that might fast track or stop new technology adoption. Technology readiness was developing, and at the same time the internet boom was increasing, leading researchers to put strategies in place to increase consumer trust in the e-commerce environment. This research looked at the advantages and disadvantages of new technology-based systems and the meaning for the consumer in accepting these technologies. Since the first publication of technology readiness, much advancement has taken place in this technology space. More internet users, the speed of the internet, the switching form normal cell phones to smartphones, the social media boom, mobile commerce, and cloud computing. With this history behind technology readiness and the experience gained over 12 years until Parasuraman’s (2000) research, the authors of the technology readiness index agreed that there was a need to streamline and update the index. A clear differentiation between the new technology readiness index and the old one needs to be made. The former was named TRI 2.0 and the latter TRI 1.0. TRI 1.0 consists of 36 belief statements, each fully anchored on the five-point Likert scale (1 = strongly disagree to 5 = strongly agree). Of the 36 statements, 10 measure optimism, seven measure innovativeness, 10 measure discomfort, and nine measure insecurity. TRI 1.0 provides dimension-specific as well as overall measures of technology readiness (Parasuraman & Colby, 2015). With the years, technology has increased and improved exponentially. The internet has progressed in terms of speed, connectivity, and access, which has had a direct effect on the attitudes and behaviours of consumers towards technology. With these changes, the language has also changed. TRI 1.0 has words like ‘machine’, ‘computer’, and ‘computer programme’, which are fast becoming outdated. In 1999, when TRI 1.0 was developed, many of today’s devices were in their infancy and some not even ideated. These were smartphones, wireless internet, social media, and home video conferencing. In addition, the 36-item index was too long. All these advancements and improvements motivated the need to relook TRI 1.0 and thus develop TRI 2.0. 17 TRI 2.0 is made up of 16 belief statements, of the 16 items, 11 are from TRI 1.0, while five have been newly added. The technology readiness statements use the same five-point scale used in TRI 1.0. One third of the items in TRI 2.0 have been reworded in keeping with the times and new technology (Parasuraman & Colby, 2015). Many companies have increased the use and adoption of technologies in the selling and marketing of their products and services to customers. Similarly, the use of technology among customers is also rapidly increasing (Parasuraman, 2000). Parasuraman (2000) noted little scholarly research on people’s readiness to use such systems. Traditionally in business there was a clear difference between goods companies and service companies, but this argument was challenged and contested by Rust (1998, as cited in Parasuraman, 2000), who stated that all companies provide a service. Research to establish the readiness of people to adopt the use of technology as a service offering was sparse. Parasuraman (2000) proposed a conceptual framework that looks at the traditional domain of marketing and what needs changing. In Parasuraman’s (2000) research, a ‘pyramid model’ of services marketing was put forward. This model is an extension of the triangle marketing model by Kotler (1994). These models are depicted in Figure 1. 18 Figure 1: Triangle and pyramid models of services marketing (Parasuraman, 2000, p. 308) The traditional 4-Ps of marketing, namely product, placement, price, and promotion or distribution forms the basis of the triangle model. The effective marketing of services looks to include two more forms of marketing: internal and interactive. Internal marketing has been used in many research papers and literary works and is accredited to the work of Berry (1981), which states that the employee of an organisation is the first customer, who needs the knowledge, education, and training internally to allow them to deliver superior service experience to customers. The impression created by the first interaction of the customer with an employee of a company through the delivery of a service is interactive marketing. According to Parasuraman (2000), internal and interactive marketing was consistent with other research by Booms and Bitner (1981) who recommended having three additional Ps: people, process, and physical environment, added to the traditional 4-Ps. However, these two types of marketing still do not cater for technology. With technology on the increase on both the goods and services 19 sides of business, as well as consumers’ use of technology, the triangle model does not capture all the complexities of services marketing. To cater for these complexities, the pyramid model adds the dimension of technology and shows three distinct relationships that need to be managed to ensure effective marketing services. These three relationships are company-technology, technology- employee, and technology-customer. Parasuraman’s (2000) first objective in this study was to set out the development of the technology readiness model and the multi-item scale to assess users’ acceptance and readiness of this model. The second objective was to investigate the scale’s psychometric properties, future applications, and use of this model. Looking at the comparison of the automobile, which took 55 years to reach 25 per cent ownership, with the cell phone that took 13 years to achieve the same ownership (Berry, 1999); although there was an increase in technology, the users of this technology were frustrated and left disillusioned with the technology (Alsop, 1999). Some of the reasons for this were first the early adopters were much more technology wise than the laggards. Second, the use and experience of technology, and third the complexity of use of the product. These reasons were the motivation to understand what factors will predict whether a user will embrace technology or not; are people ready to use technology and do demographics affect the use of technology (Parasuraman, 2000). This gave rise to the development of the technology readiness index with the main aim of assessing people’s technology readiness. Many studies have been conducted on the technology readiness, which differentiates users as either being positive towards new technology or negative. Users with positive attributes adopt and embrace new technologies more easily, while users with negative attributes shy away from using new technology. There were different technology contradictions that looked at a more general overview of technology readiness of people as outlined in work by Mick and Fournier (1998) and Davis et al. (1989), which looked at specific consumer motivation and beliefs behind the adoption and readiness to embrace technology. The above- mentioned studies, together with some qualitative work formed the foundation of 20 this research to understand the development of technology readiness and its future applications. Parasuraman’s (2000) development of the technology readiness index was a collaborative effort with an organisation that tasked him with the objective of trying to understand the attitudes and behaviours of technology readiness for a client they were commissioned to work with. This study took many years and adopted both qualitative and quantitative evidence. The qualitative research took the form of focus groups, which had well set out themes around being positive and negative. Flexibility, convenience, enjoyment, and efficiency were the positive factors and security concerns, users lacking of control, technology being impersonal, and the risk of the technology becoming obsolete made up the negative factors (Parasuraman, 2000). Another study, the Salae Mae study (Parasuraman, 2000), researched customer’s openness to various technology-based services using 44-item survey and a five-point Likert scale. The sample size was 3 000 people, and results rendered 1 200 useable responses. The ratings received underwent a series of statistical analysis leading to a shortened scale of 28 items differentiated into four categories: (1) Optimism: A positive view of technology and the belief that it adds value by offering people increased control, efficiency, and flexibility in their lives; (2) Innovativeness: The tendency to be the first adopter and mover on technology, as well as a thought leader in this area; (3) Discomfort: Lack of control over the technology and having a sense of being overwhelmed by the technology; and (4) Insecurity: When trust in technology is lost and respondents display scepticism about the use and belief of what the technology can do. Optimism and innovativeness are the positive factors in technology readiness, whereas discomfort and insecurity are negative factors, stalling and sometimes stopping the use of technology. These subscales of the technology readiness 21 scale appeared to be good predictors of technology-based behaviour. The technology readiness index is a sound psychometric multi-item scale that companies can use to gain a thorough understanding of their customers readiness to interact with new technology, especially computer or internet-based technology (Parasuraman, 2000). In addition, it can be used by companies to assess the readiness of its employees to either embrace or reject new technology. In the framework of researching technology readiness, another study looked at the readiness of physicians using smartphones in clinical practice. Historically physicians walked around with pagers, which had a direct impact on the hospital budget; they were expensive. The introduction of the smartphone revolutionised this and replaced the pager, bringing with it a decrease in diagnosing errors and prescriptions. As the internet and hospital information technology increased the advantage was an overall cost reduction (Putzer & Park, 2012). The study examined the innovation characteristics of compatibility, job relevance, internal environment, observability, personal experience and the external environment. All these characteristics have an impact on physicians’ attitude towards the use of smartphones. On compatibility, if physicians found that smartphones are connected to the hospitals’ other information technology related offerings then their attitude is positive toward the adoption of smartphones. Hence, hospital infrastructure needs to consider the support structure in terms of bandwidth, network monitoring, and synchronizing capabilities with desktops in the hospital. The legal implications entail the capturing of doctors’ personal information. Practicality and job relevance in the use of a smartphone was another important factor, if physicians found that the device brought about better patient care, a positive attitude towards the use of the device was evident (Putzer & Park, 2012). Physicians’ personal experience and interactions with the innovative characteristic was important in this study although previous findings by Putzer and Park (2012) found mixed results between physicians and nurses. The explanation was that in their study’s sample more than 50 per cent of physicians 22 were older, much more experienced in clinical practice, and needed more exposure to become accustomed to the devices. The internal environment proved a significant predictor of adoption and use of the smartphone; it involved the support physicians received from the hospital structure with regard to networks, budgets set aside for smartphones, and technology support, which proved to be critical in physicians’ attitudes to adoption of the technology. The relevance of the use of smartphones in making better clinical decisions for the patient has now been widely supported by hospital policies and procedures, and technical support is now in place. Smartphones have since increased in functionality and capabilities, which has given rise to the increase of technology and is here to stay (Putzer & Park, 2012). 2.4 Detailing to healthcare professionals With all the glitz and glamour that technology brings, the main objective of every healthcare system is the delivery of services by one set of professionals to those in need of services to maintain and improve overall health. This transactional exchange of services is founded on a set of skills, knowledge, values, expertise, relationships, and trust that patients invest in doctors to get the best and most effective treatment. Through time and interactions, this trust is earned through a special set of skills, ethical duties, commitment, and social accountability, which forms the core of professional work (Frenk et al., 2010). Obtaining and developing this mix of characteristics requires lengthy periods of study, education, and investment from the medical student and society. The professional medical education that a doctor undertakes is one of the key attributes in delivering high quality, safe, and effective services to communities. With the advancement and the pace of technology, education in the medical profession has not kept pace. Into the twenty-first century and more recently there still exist major holes in the professional education of doctors and pharmacists. The discovery of new science, best clinical practices, fresh challenges, and demographic transitions has not kept pace with the professional education of healthcare professionals (Frenk et al., 2010). 23 In reports calling for reformation in medical education, it is noted that before the celebrations of 100 years of the Flexner report, there was a heightened awareness of and focussed attention on, nationally and internationally, the future of education of health professionals. The four sets of major reports, as mentioned in section 1.2 of this research report, calls for the focus on education of the global workforce, nursing education, public health education, and medical education. In fact, these reports call for a reform in education that emphasise patient and population centeredness, competency-based curriculum, inter-professional, and team-based education. These areas will form a strong base for formulation of reform initiatives for the twenty-first century. All reports proposed an investment in education and training, sharing of resources and partnerships within and across countries (Frenk et al., 2010). A lot of research has been done by Manchanda and Honka (2005) in the area of the effects of the role of direct physician marketing in the pharmaceutical industry. Face-to-face doctor detailing does have its positive and negative attributes as it drives education driven, changes scripting behaviour patterns, and builds relationships. The proposal put forward is that the experience of face-to-face detailing needs to be effective and used in the best possible way, practice ethical marketing, and allow for a mixed model of incorporating e-learning to reach doctors not reached by pharmaceutical representatives in face-to-face detailing (Manchanda & Honka, 2005). Education of doctors driven by detailing can take the form of face-to-face detailing or in a group, like lunch and breakfast appointments. Research looked at the benefits of these two types of detailing, the motivation was that it was noticed that there was an increase in prescriptions of anticholinergics to the elderly, which led to higher side effects and contributed to a decreased life span. The aim of this detail exercise was to drive CME to both pharmacists and doctors, and to bring about a reduction in the prescriptions of these drugs and thus the knock on effect of reducing the dispensing of these drugs (Van Eijk, Avorn, Porsius, & de Boer, 2001). The findings of this study were conclusive in that both individual and group detailing brought about a change in behaviour and drove fewer prescriptions of anticholinergic drugs among the elderly. 24 The differences highlighted in group detailing is that there was more conformity, which was attributed to peer pressure; with individual, face-to-face detailing it was noted that healthcare professionals were much freer to talk about their prescribing habits. In this study, both individual, face-to-face detailing and group detailing changed prescribing behaviour. This prescribing behaviour can be attributed by the frequency of the visiting detailing representatives; more visits meant the delivery of the same key messages, which drove top-of-mind behaviour and prescribing habits. For physicians, choosing an individual drug is one of the most important clinical decisions in a medical practice. The prescribing decision is influenced by many factors such as patients providing information to doctors on what they are experiencing, commercial drive by pharmaceutical companies, colleague influence, medical journal articles, and government regulations (Soumerai, McLaughlin, & Avorn, 1989). In this research, it was found that the older population, above 65 years of age, were taking more prescription drugs. Prescribing behaviour in such age group is critical due to the adverse events of drugs in this population and prescribing behaviour can influence their quality of life and life span. Strangely enough there is an over prescription of drugs in this age group. This study looked at non-regulatory methods and its effect on changing prescribing behaviour patterns to reduce over-prescription of drugs. One of these methods looked at face-to-face educational detailing to change behaviour patterns. Several health education studies that show evidence of one- on-one education can effectively change behaviour patterns; such an example is changing behaviours in smokers (Leventhal & Cleary, 1980). Soumerai et al. (1989) also made mention of this method being effective in his previous studies. As mentioned, pharmaceutical companies train their medical representatives to detail doctors with the purpose of changing prescribing behaviours. One of the key reasons for prescribing errors in a clinical setting is over zealous medical representatives and relationship-based selling. The results from this study (Soumerai et al., 1989) showed that one-on-one education of physicians by a visiting pharmacist or counsellor brought about a change in prescribing 25 behaviour. The pharmacist or counsellor in this study was the medical representative. There are several studies showing that detailing supports behaviour change, brings about better clinical outcomes for the patient, and reduces prescribing errors. Another study showed a different benefit of detailing: culture. In the US, many medical doctors failed to understand the minority cultures when treating patients. This lack of knowledge in understanding the different cultures created huge differences in healthcare treatment when it came to the minority versus their white counterparts (Horner et al., 2004). The literature review showed many studies examining reasons for, and consequences of, observed racial, ethnic, gender, and socioeconomic differences in the management of many conditions across different therapeutic areas of cardiovascular disease, central nervous system disorders, cancer, and pain management. Upon these findings, the medical fraternity put together a task force to address these differences and generate a plan to rectify this situation. This task force was a representation of different healthcare professional bodies and medical academic institutions. The healthcare professionals did not understand the health system and came with their own mindsets on racial, ethnic, and social class. Their lack of awareness on these attributes meant they did not understand their patients, which led to incorrect diagnoses and treatment plans. These professionals lacked cultural competence. The working group was to establish a set of recommendations that would be effective in driving behaviour change in these health professionals. One of those recommendations was educational outreach, which took the form of detailing on cultural competence, and was found to be effective in changing behaviour. Another study (Horner et al., 2004) made mention that this type of detailing should be part of the classroom setting for healthcare professionals. Training of cultural competence and supporting a diverse workforce is an area that needs attention and can take several forms:  Providing healthcare professionals and staff with continued education on cultural competence; 26  Availing practical resources to doctors to be cross-culturally sensitive;  Putting incentives in place for staff by means of textbooks, journals, and access to internet; and  Providing transportation and interpreters where needed. Cultural competence training at medical schools in the US and the United Kingdom vary, but overall the numbers focussing on this is low. Research has shown that detailing is effective in changing behaviour, and this behaviour can be changed to reduce disparities in the healthcare system of diagnosing and treating patients from different cultural backgrounds. By comparison, detailing in South Africa is limited, and further research is needed to look at how product e-detailing is transforming traditional pharmaceutical marketing. Prior to 1997, direct marketing to consumers was very limited, Pharmaceutical companies, as mentioned earlier, continued driving education with doctors via detailing (Trucco & Amirkhanova, 2006). Research in US pharmaceutical companies showed that the cost of detailing took a huge share of the marketing budget, between 45 and 70 per cent. In Europe this figure is even more significant as the direct consumer advertising spend is low (Bates, Bailey & Rajyaguru, 2002). The main objective of detailing is to gain market share of the products they detail and thus drive up company profits, and in the interim build strong relationships. Over the years, a major shift has occurred to challenge detailing efforts due to trends and radical changes in the industry to drive ethical marketing. These changes are as follows:  Introduction of new policies and procedures locally and globally;  Generic products and clone products as original drugs lose their patency;  Increased demand of doctors time as more detailing representatives flood the market; and  Rising costs of research and development. 27 Traditionally if there were inefficiencies in the sales force, this was addressed by increasing the number of medical representative, thus increasing the reach to new doctors and increasing the frequency of calls to A-listed doctors. The sales representative force globally increased by an average of 21 per cent from 1999 to 2001. This increase has been strongest in the US, with 42 per cent, and the least in Japan, with 1.2 per cent. However, this cannot be a long-term solution, as the return on investment (ROI) of the representatives will start to outweigh the profits generated. In addition, having numerous representatives in an area means that they compete for the doctors’ time, a 15 minute call could reduce to five minutes as doctors need to make time to see other representatives. Some doctors go to the extent of refusing to see any representatives because of the influx of so many of them in the field. It has been noted that in countries like the US, the number of medical graduates annually has been a steady flat number, but the medical representative force has been doubling. The marketing exercise of targeting and segmenting has seen the detailing efforts focused on the high potential, high prescribing doctors. It means these doctors are being flooded by representatives demanding their time; all competitor pharmaceutical companies are doing the same, all competing for the doctors’ time. The detailing cycle planning includes two priority detailing products, some companies will have a third as a reminder product. With the pressure and line up of these products on the representatives detailing cycle, the effectiveness of detailing is not beneficial on message delivery and recall. The combination of all these factors have led to an ever-decreasing ROI for the pharmaceutical companies, that leaves a major gap in educating doctors if pharmaceutical companies want to see profits from sales increasing (Trucco & Amirkhanova, 2006). 2.5 Barriers to innovations The medical profession is one sector that thrives on research and clinical trials, it boasts a sector rich in medical science discoveries. Having stated this, major gaps in knowledge remain when it comes to putting this knowledge into clinical 28 daily practice (Berwick, 2003). This gap is described in the Institute of Medicine Report; there is a divide between what science has delivered and the healthcare provided. In the US, this is a huge problem, as alluded to earlier in this research, due to the lack of knowledge, dispensing errors and treatment regimens have been affected. It is one thing discovering an innovation; however, the actual rate of dissemination of this innovation can take much longer, as seen in Rogers’ (2010) work in Iowa State, with the seed corn innovation. The rate of diffusion and dissemination of innovations is often a long process; Berwick (2003) researched the barriers to innovation and what makes dissemination successful. As in Rogers’ (2010) study on diffusion of innovations, it took the farming community 13 years to adopt the seed innovation. In the diffusion of innovations studies by Rogers (2010) and Van der Ven’s (1999) work on innovation research, and many others, they focussed on three basic clusters of influence that enables a diffusion to disseminate. They looked at (1) perceptions of innovation; (2) characteristics of the people who adopt the innovation, or fail to do so; and (3) contextual factors, especially involving communication channels, incentives, leadership, and management. For an innovation to have a successful adoption in a system, Rogers (2003) and Berwick (2003) highlighted five characteristic perceptions of innovations: (1) Relative advantage of the innovation; (2) Compatibility; (3) Complexity; (4) Trial ability; and (5) Observability. 29 2.5.1 Relative advantage Any innovation needs to give the user an advantage of being more effective and efficient; in addition, the cost of the innovation as well as what it would take to maintain. Social motivation is another factor of relative advantage. While the early innovators, early adopters, and early majority are status motivated, the late adopter and laggards do not perceive status as important. To increase the rate of adoption and make the innovation relative, direct and indirect payment incentives can be in place to motivate the adoption of the innovation (Rogers, 2003). Education plays a critical role in the adoption of an innovation, the more knowledge shared on the innovation the more likely it is to be adopted, Rogers (1995) calls this ‘reduction in uncertainty’. 2.5.2 Compatibility Everyone has a system of beliefs, attitudes, and values. Rogers (2003) stated that compatibility occurs when the innovation is consistent with existing values, past experiences, and the needs of potential adopters. If individuals do not have experience in technology or the use of it, this will affect their ability to adopt an innovation in this sector and thus few will use the innovation (McKenzie, 2001). In a literature review by Hoerup (2001), innovations influence teachers’ opinions, beliefs, values, and views about teaching. Another key factor is the naming of the innovation, as users associate themselves with brands and names. Values, beliefs, history, and current needs of the individual affect the rate of diffusion of an innovation. At times in the medical profession, it is noted that only a minority of doctors will use scientific guidelines and algorithms in treating their patients (Casillino et al., 2003). This is largely due to the surgeon or physician’s stubbornness towards the use of the innovation, or a mismatch of the innovation serving the current needs of the practice and thus the healthcare professional does not see the need to adopt the innovation (Berwick, 2003). 30 2.5.3 Complexity According to Rogers (2010), complexity is the degree to which the user perceives the adoption as being difficult to understand and use. Simplicity and ease of use is paramount in an innovation. With so many technological advancements, grappling with understanding how to use innovations should be minimal. If the innovation does not meet such criteria, then the rate of adoptions is much slower. Successful adoption depends on the ease of use of both the software and hardware of the innovation. Most of the time the developer of the innovation is not a good salesman and is more interested in its elegance, seeing the innovation as being something that can be replicated once it is adopted and adapted to meet the local needs (Berwick, 2003). 2.5.4 Trial-ability Trial-ability, according to Rogers (2003), is the testing of or experimenting with the innovation for a limited period; a trial run. Some companies use what is referred to a test market, and during this period troubleshooting takes place and adjustments made so that the rate of adoption can be quick and ease of use ensured. Feedback is given on what is working, what is not, and how the innovation can be improved. This is also is an example of best practices sharing, and if other individuals and markets see the value the innovation brings, then they are more likely to adopt the innovation. 2.5.6 Observability When the innovation becomes visible to others and they see it in use, this is observability, as defined by Rogers (2003). Users and observers need to see the benefit of the innovation as a solution to a problem; this is vital to the rate of diffusion. The adoption of a new idea or innovation is not an easy process, for an adoption to be successful; these barriers to innovation (section 2.5) need to be taken into 31 account to ensure the rate of adoption is impactful and the diffusion process speedy (Rogers, 2003). The change in attitudes, behaviour, and adoption diffuses faster when these factors are applied to the innovation (Berwick, 2003). The Canadian health heart kit (HHK) research is a study that applied these factors to an innovation that was built on the constructs of Roger’s (2010) theory of diffusion and the theory of planned behaviour. According to the theory of planned behaviour, an individual’s aim to perform the set behaviour is vital to performing the behaviour, as is the motivation as a key driver behind the behaviour (Ajzen, 1991). In Berwick’s (2003) study, he makes mention that Eccles et al. (2006) suggested that there is a predictable connection between healthcare professional’s objective to engage in behaviour and their succeeding behaviour. The two main aims of the Canadian HHK research were to find out (1) if there were specific factors of the HHK as well as circumstances and situational factors that contributed to the aim and actual use of the kit; and (2) if any situational or other circumstantial factors are associated with individual or environmental barriers that prevent the uptake and adoption of the kit among physicians who do not intend to use it (Scott, Plotnikoff, Karunamuni, Bize, & Rodgers, 2008). The decision to adopt an innovation is not a linear path, but highly multifaceted, a dynamic and active process that involves interactions between individuals, situational factors, different circumstances, and considerations of the attributes of the innovation itself. 32 Figure 2: HHK’s multi-faceted paths (Scott et al., 2008, p. 6) As mentioned in section 2.5, the two key attributes of the study (Scott et al., 2008) was relative advantage and observability. An innovation that has a clear advantage over another will be adopted should the need arise. The advantage can be conceptualised in terms of economic profit, social prestige, or ease of use. Observability of the benefits of using the HHK was another attribute that ranked high in this study on the intentions to use the kit. The outcomes show that the adoption process is not linear and straightforward but that contextual factors, attributes of the innovation, and situational factors play a critical role in the adoption process and the innovation diffusion, as depicted in Figure 2. 2.6 Detailing representatives adding value to CME of doctors Pharmaceutical companies invest a lot of time, money, and resources in equipping representatives to get a clinical message out to doctors. This detailing process involves the promotion of drugs and is effective in the early life cycle stage of drug marketing, with incremental returns on investment. Research and development of a next originator or ethical drug takes years to discover and manufacture. The representative thus continues detailing a product over a very long period after the early life cycle of the drug, the efficacy of the detailing process is questioned as to whether the process continues to add value or new education to doctors (Manchanda & Honka, 2005). This process of face-to-face detailing increasing becomes a relationship-based selling tactic used by pharmaceutical companies with the main aim of driving repeated messaging and re-enforcement (Fugh-Berman & Ahari, 2007). Pharmaceutical companies segment, target, and profile doctors according to the amount of scripts they write and the potential of their scripts (Soumerai & Avorn, 1990). The Flexner report, discussed in sections 1.2 and 2.4, is a report on medical education, 100 years from 1910, a series of requests and proposals have gained 33 local and international attention on the reform of medical education (Flexner, 2002). This heightened awareness has been included as part of the MDGs. The MDG report, in addition to three others detailed in section 1.2, all stress the importance of education and training in the medical fraternity. The joint request of these reports calls for an incremental increase in investment in medical education, best practices sharing, along with sharing of resources and partnerships within and across borders (Frenk et al., 2010). Health is all about people, the professional development of doctors encompasses life-long learning either formally or informally. Effective healthcare requires continuous learning (Bennett et al., 2000). As noted in section 2.4, not all doctors are visited by pharmaceutical representatives. The face-to-face detailing process provides an avenue for doctors to be susceptible to the influence of pharmaceutical companies; the gift bearing involved, the relationships built, and the tactfully and carefully selected messages (Fugh-Berman & Ahari, 2007). Pharmaceutical companies target doctors that add to the net revenue and profits; therefore, the education gap between detailed doctors and non-detailed doctors is widening, and is not in line with the MDGs and other reports. Research has shown that detailing by representatives adds to the CME of doctors and is a key factor that changes behaviour. All in the name of science, the medical profession has been plagued for many years with misdiagnoses and incorrect prescriptions adding to and increasing the death rates (Choudhry, Fletcher & Soumerai, 2005). One way to address this critical gap in education that exists is by doctor detailing. This was proved in a hospital setting where vasodilators were incorrectly prescribed (Soumerai & Avorn, 1990). Pharmacists were trained in selling skills and pharmacotherapy to visit physicians to educate them in bringing about change in their behaviour pattern and prescribing habits of vasodilators. The pharmacists in this case where the detailing representatives. On the first detailing visit, there was no difference in behaviour, when key educational messages were repeated on the second visit; behaviour change was noted (Soumerai & Avorn, 1990). Other studies have concluded positive changes in prescribing behaviour 34 thus decreasing prescribing errors when face-to-face doctor detailing was employed (Soumerai & Avorn, 1984). Educating doctors and changing their prescribing behaviours meant huge cost savings due to prevention of prescribing errors and misdiagnosis of medical conditions. In view of the fact that representatives change the behaviour patterns of prescribing doctors there is very little quantitative evidence on the impact they have, the evidence (Hemminki, 1977) that does exist is broad sales presentations on survey results. Soumerai and Avorn (1990) set out to research and understand if the representatives could change prescribing behaviour of physicians by detailing and educating them, which adds to their continued professional development. The medical detailing can be likened to a non- government organisation, as the pyramid of influence is similar and detailing looks at spreading of education. The objective of the research was to find out if the representatives were adding value to doctors’ prescribing behaviour. The prescription of antibiotics has always been a contentious issue due to the over- prescription of these drugs. Previous research looked at the over-prescription of antibiotics and a behavioural change strategy to stop this problematic activity, and instead lead patients to self-care and over the counter medications like aspirin (Soumerai & Avorn, 1986). The analysis of the impact of detailing was based on different techniques and principles used to bring about behaviour change. Adult-based education, diffusion of innovation, and communication were the techniques used. The motivation behind doctors’ prescribing of a product is important to understand the impact that face-to-face detailing would have. It is misleading to believe that the delivery on CME to doctors alone will bring about a shift in prescribing behaviour and effective treatment for the patient. The discovery of new clinical science has, in some cases, brought about a change in prescribing behaviour; research has also shown that the personality, attitudes, behaviour styles, competitive landscape, competitor activities, peer influence, and CME strategies form part of the detailing mix (Soumerai, McLaughlin, & Avorn, 1990). The representative is extensively trained and educated to use this information in their detailing calls to doctors. 35 In detailing to medical professionals, the source of information is critical, as this is associated with the credibility of the message. The research centre of the trial, the journal in which the trial was published, the key researcher in the trial, all these factors are what makes the message credible. Pharmaceutical representatives are trained to deliver these messages, so they come across as being credible. Symposiums are also sponsored by pharmaceutical companies and the attending doctors are met with representatives delivering the key messages when they interact with doctors at the exhibition booths at medical symposiums (Bowman, 1986). Detailing representatives are also highly incentivised to achieve sales targets; however, this leads to overzealous representatives delivering messages to achieve a sales target. In the delivery of this type of message, the credibility of the message is brought into question. During Soumerai and Avorn’s (1990) research, doctors have not fully confessed that they have been swayed by representatives and the relationships they have. Ethical medical practice should be based on the science and thus lead to effective clinical decisions for best outcomes for both patient and treating doctor (Soumerai & Avorn, 1990). The time to see a representative can be easily substituted and channelled to spend more time on seeing a patient. Doctors dedicate time in their busy schedules to seeing representatives and when asked why they do this, most did not even have an answer to this question. It felt to them like it was part of their job. Some found representatives to waste their time, but still found time to see them. A study that looked into the reasons that physicians refuse to see representatives stated that these appointments were taking too much time in a day, and that the trinkets and gifts they brought creates bias and this sways the doctors’ prescription habits (Brody, 2005). However, having stated this, this practice of seeing representatives has not changed since 1961, and every year pharmaceutical companies continue to employ representatives to call on high potential, high prescribing doctors. Brody’s (2005) study showed that doctors felt compelled to see representatives due to the gifts received and that prescribing became personal. A more robust way to 36 verify the educational content delivered by the representative would have been to receive the information and then spend time reviewing the clinical evidence to verify the content given by the representative. The decision then lies with the doctor to prescribe the correct medication and dedicate their time to the patient and treatment diagnosis and regimen. If doctors spend time with representatives, and are swayed with gifts and trinkets, then the ethics and integrity of the profession is questioned. Representatives are business people that are being loyal to their employers in delivering key clinical messages, the integrity of doctors is solely in the power of the doctors’ hands and the representative is not responsible for the integrity of doctors. Detailing to doctors involves a multifaceted approach and, in another study, Soumerai et al. (1990) researched the quality assurance of prescriptions and investigated seven pillars that assisted the representative in the detailing process. These pillars are: (1) the use of printed educational materials in the form of leave behinds; (2) the list of medications that patients were prescribed; (3) group gatherings in the form of breakfast, lunch, and round tables; (4) qualitative feedback of prescribing habits of physicians; (5) reminders by the representatives at times of prescribing; (6) detailing that involved face-to-face interaction; and (7) continued ongoing pharmacy services. The use of printed educational materials alone matches the findings in previous literature that education in the form of pamphlets, fact sheets, unbranded advertorials, and leave behind materials does change the attitudes of doctors; however, it does not change prescribing behaviour (Soumerai et al., 1990). Sending a list of the patients’ drugs without any proper instructions, reports, and findings did not change the prescribing behaviour of doctors in any way (Hershey, Porter, Breslau & Cohen, 1986). There is little research on group learning changing prescribing habits. Group education is a common practice in the medical profession; universally many doctors work in corporate groups. It was found that when senior physicians led the discussions, and were seen as key opinion leaders (Inui, Yourtee, & Williamson, 1976), they were able to influence 37 and bring about a change in prescription behaviour in terms of antibiotics and hypertension (Klein, Charache, & Johannes, 1981). In terms of feedback on prescribing patterns, the past habits of doctors were compared to their present habits and with that of their peers. It was found that this did influence behaviour and change prescribing habits; however, not many findings are conclusive in this category. One study was well controlled and showed a generic prescribing of 46 per cent over the controls (Gehlbach et al., 1984), which proved that with adequate feedback prescribing behaviours can be changed. Many interventions looked at reminders to doctors at the time of prescribing, even though education was taking place, this did not pose a problem, but it was something that doctors overlooked. The most recent study failed to show the effectiveness of either reminder or feedback on physicians’ compliance with other drug protocols (Tierney, Hui & McDonald, 1986). As mentioned in section 2.4, the one-on-one detailing by representatives to doctors does contribute to their education and changes prescribing behaviours. This has been seen in antibiotic prescriptions, scripting of vasodilators, cardiovascular drugs, and even smoking cessation (Soumerai & Avorn, 1990). Detailing does contribute to the medical education of doctors and their professional development. In the detailing to doctors and adding to their continued professional development, one specific area that doctors were questioned on was conflict of interest and their handling of this issue (Chimonas, Brennan, & Rothman, 2007). Many surveys were carried out and many inconsistencies remain; some doctors believe that seeing representatives and receiving gifts is part of their educational development (Keim, Sanders, Witzke, Dyne, & Fulginiti, 1993), while others believe that this shows bias towards the representatives and company behind the products. Several surveys carried out showed that doctors were not aware of the negative effectives of the detailing and their relationships with representatives. They justified their relationships as part of their job and necessary to their professional development. 38 The methodology followed focus groups among physicians, which was an excellent format to understand how physicians managed the inner conflict of manufacturers trying to sell a product, while they were trying to maintain their integrity and have patient care at the forefront (Chimonas et al., 2007). Since, the pharmaceutical industry, medical bodies, and governments have put in place legislation to make sure that unethical practices do not take place between pharmaceutical companies and doctors. The trend in the 1970s and 1980s saw a huge investment from pharmaceutical companies sponsoring CME of doctors and thus adding to their continued professional development, be this in the form of detailing by representatives, round table dinners, or national and international symposiums. Over the years, the pharmaceutical industry has come under heavy legal and regulatory scrutiny and seen policies and regulations put in place. This was instituted by the Accreditation Council for Continuing Medical Education (ACCME), which accredits all CME providers, and put in place policies and procedures to identify, disclose, and resolve conflicts of interest (Steinman, Landefeld & Baron, 2012). With the decline of industry support of CMEs, physicians are concerned about their CME and thus their continued professional development. The shift has already been seen with medical schools moving CMEs to their facilities and lecture rooms. This means that there is no cost for conference venues, accommodation, and transport. This money can be channelled into other avenues that can help medical teaching hospitals. This shift is also taking place from traditional physical attendance to online interactions; however, physicians feel they will miss the opportunity of listening to key opinion leaders on various subjects and thus the knowledge deficit will widen. Reducing funding for accredited CMEs also poses a problem for pharmaceutical companies having their own CMEs in restaurants and other venues, which mean that education is not accredited and standardised, adding to confusion and lack of clarity on education. Industry support for accredited CME is unlikely to disappear totally from the profession, time will tell as tighter restrictions from a regulatory and economic perspectives is seen more frequently. This shift calls for 39 the medical profession to make a cross-functional collaborative effort with physicians, accredited CME providers, and pharmaceutical companies to work together for the main purpose of better education and patient outcomes (Steinman et al., 2012). 2.7 Academic detailing to improve clinical decision-making Healthcare is not affordable for many, and with the cost of drugs increasing, it is important that these drugs be prescribed as rationally as possible; this is not happening. The drugs doctors’ choose to prescribe for the patient, and the cost of the drug often falls short of the desired clinical outcome due to adverse reactions to the drug. Several theories and principles of communication and behaviour change can be found that underlie the success of pharmaceutical companies in influencing prescribing practices (Soumerai & Avorn, 1990). Pharmaceutical representatives have been operating for more than 100 years. In the US, Soumerai and Avorn’s (1990) research on representatives showed numbers of approximately 28 000. Pharmaceutical companies have a high annual investment in detailing representatives. Several studies indicate that representatives are the first point of contact for information dissemination to doctors. Detailers do shape much of the prescribing behaviour, but there is a lack of scientific literature on how they might adapt their detailing to reduce prescribing behaviour. Medical representatives often employ incentive strategies to all personnel in the medical profession, nurses, receptionists, theatre sisters, and doctors. The objective behind this tactic is to gain entry and time with selected, targeted doctors to deliver a clinical, medical marketing message. One of the key credentials to recruit a medical representative is for them to have a scientific, health sciences, educational background so that they can converse with doctors and be successful at undergoing a rigorous training programme on clinical science, sales, and marketing. The motivation behind their task is further enhanced by huge incentives, like overseas trips, if they exceed their sales targets through doctors they detail. This is a hazard as you get over-zealous 40 representatives trying to push a message through with the sole purpose of generating additional income, instead of having doctors and patients in mind for the best, cost effective treatment (Soumerai & Avorn, 1990). From this angle, many physicians have questioned the credibility of the messages from the representatives on product efficacy. In some instances, these incentives have led representatives to deliver the wrong messages on the drugs being detailed. The way educational information is diffused by pharmaceutical companies is at times misleading to doctors. In 2012, giants such as GSK (Thomas & Schmidt, 2012) and Eli Lilly we