Reversible phosphorylation of proteins in proliferating and differentiating cells: cyclic variations and the effect of growth regulators
Date
1994
Authors
Ferreira, Gracinda Maria Nunes
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Abstract
Living cells are highly auto-dynamic entities which means that the
underlying biochemistry is equally dynamic, a reality which is ignored
by most researchers.
Theoretical studies indicate that such a state must be due to the
existence of oscillatory variations in the levels and activities of key components in the cell. In this study, the dynamic behaviour of four
major, interrelated areas of cell biochemistry (phosphorylation,
dephosphorylation, the terminal reaction of glycolysis and the amount
of soluble protein) were examined and all systems found to oscillate
in murine erythroleukaemic cells (MEL) and, where examined, also
in the human HL-6Q leukaemic cell line. [Abbreviated Abstract. Open document to view full version]
Description
A Dissertation Submitted to the Faculty of Science
University of the Witwatersrand, Johannesburg
In fulfilment of the requirements
for the Degree of Doctor of Philosophy
Johannesburg 1994
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Citation
Ferreira, Gracinda Maria Nunes (1994) Reversible phosphorylation of proteins in proliferating and differentiating cells: cyclic variations and the effect of growth regulators, University of the Witwatersrand, Johannesburg,<http://hdl.handle.net/10539/23022>