4. Electronic Theses and Dissertations (ETDs) - Faculties submissions
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Item Engaging the public in priority setting for health in rural South Africa(University of the Witwatersrand, Johannesburg, 2023-10) Tugendhaft, Aviva Chana; Hofman, Karen; Kahn, Kathleen; Christofides, NicolaIntroduction: The importance of public engagement in health priority setting is widely recognised as a means to promote more inclusive, fair, and legitimate decision-making processes. This is particularly critical in the context of Universal Health Coverage, where there is often an imbalance between the demands for and the available health resources. In South Africa, public engagement is protected in the Constitution and entrenched in policy documents; yet context specific tools and applications to enable this are lacking. Where public engagement initiatives do occur, marginalised voices are frequently excluded, and the process and outcomes of these initiatives are not fully evaluated. This hampers our understanding of public engagement approaches and how to meaningfully include important voices in the priority setting agenda. The aim of this doctoral (PhD) research was to investigate the feasibility and practicality of including the public in resource allocation and priority setting for health in a rural setting in South Africa using an adapted deliberative engagement tool called CHAT (Choosing All Together). Methods: The PhD involved the modification and implementation of the CHAT tool with seven groups in a rural community in South Africa to determine priorities for a health services package. For the modification of CHAT, desktop review of published literature and policy documents was conducted, as well as three focus group discussions, with policy makers and implementers at national and local levels of the health system and the community, and modified Delphi method to identify health topics/issues and related interventions appropriate for a rural setting in South Africa. Cost information was drawn from various national sources and an existing actuarial model used in previous CHAT exercises was employed to create the board. The iterative participatory modification process was documented in detail. The implementation process was analysed in terms of the negotiations that took place within the groups and what types of deliberations and engagement with trade-offs the participants faced when resources were constrained. In terms of the outcomes, the study focused on what priorities were most important to the rural community within a constrained budget and the values driving these priorities, but also how priorities might differ amongst individuals within the same community and the characteristics associated with these choices. Qualitative data were analysed from the seven group deliberations using the engagement tool. Content analysis was conducted, and inductive and deductive coding was used. Descriptive statistics was used to describe the study participants using the data from a demographic questionnaire and to show the group choices from the stickers allocated on the boards from the groups rounds. The investment level (sticker allocation) of all study participants was recorded at each stage of the study. From these the number of stickers allocated to each topic by the participants was calculated by adding up the number of stickers across interventions selected by the participant by topic. The median and interquartile range across study participants was calculated for the topic totals. To examine differences in sticker allocations, Wilcoxon rank sum tests were performed for differences across participant categories and sticker allocations in the final round of CHAT. Findings: Based on the outcomes, seven areas of health need and related interventions specific for a rural community context were identified and costed for inclusion in the CHAT board. These include maternal, new-born and reproductive health; child health; woman and child abuse; HIV/AIDS and TB; lifestyle diseases; quality/access; and malaria. The CHAT SA board reflects both priority options of policymakers/ experts and of community members and demonstrates some of the context specific coverage decisions that will need to be made under NHI. The CHAT implementation shows that the rural communities mostly prioritised curative services over primary prevention due to perceived inefficacy of existing health education and prevention programmes. The exercise fostered strong debates and deliberations. Specifically, the groups engaged deeply with trade-offs between costly treatment for HIV/AIDS and those for non-communicable disease. Barriers to healthcare access were of particular concern and some priorities included investing in more mobile clinic. The individual level priorities were mostly aligned with societal ones, and there were no statistically significant differences between the individual and group choices. However, there were some statistically significant differences between individual priorities based on demographic characteristics such as age. The study demonstrates that giving individuals greater control and agency in designing health services packages can increase their participation in the priority setting process, align individual and community priorities, and enhance the legitimacy and acceptability of the decision-making process. In terms of reconciling plurality in priority setting for health, group deliberative approaches help to identify social values and reconcile some of the differences, but additional individual voices may also need to be considered alongside group processes, especially among the most vulnerable. Conclusion: This research marks the first instance of modifying and implementing a deliberative tool for priority setting in a South African rural context. The findings shed light on the process and some of the outcomes of this approach within a vulnerable community, offering insights into public engagement in priority setting more broadly. The study demonstrates that participatory methods are feasible in modifying public engagement tools such as CHAT and can be adapted to different country contexts, potentially enhancing the priority setting process. Regarding the implementation of CHAT, the study provides an example of how a rural community grappled with resource allocation decisions, considered different perspectives and societal implications, and set priorities together. The research also highlights the priorities of this rural community, the social values driving their choices, and individual characteristics that are important to consider when setting priorities. The work demonstrates that meaningful public engagement includes various factors that interrelate and impact one another and that could inform a dynamic and cyclical approach going forward, as well as the importance of transparency during all stages of the process.Item Factors associated with HIV knowledge among younger adolescents aged 12-14 years old in South Africa(University of the Witwatersrand, Johannesburg, 2024) Makgale. Tswelopele1.Background In 2019, there were 1.7 million adolescents aged 10-19 living with HIV globally, with 1.5 million in sub-Saharan Africa and 360,000 in South Africa. Early sexual debut, defined as having first intercourse at or before age 14, has significant consequences for adolescents worldwide. While sexual activity during adolescence is normal, early sexual debut is linked to risky behaviours. While efforts have been made to understand HIV/AIDS knowledge among older adolescents and young adults, research often neglects younger adolescents aged 12-14 years old. Poor HIV knowledge among this age group may increase transmission risk, delay diagnosis and treatment, and fuel stigma. It's crucial to focus on this age group to eradicate the disease, although research is limited due to the sensitive nature of discussing HIV/AIDS with younger adolescents. 2.Objective The two set objectives of this study were firstly, to examine levels of HIV knowledge among younger adolescents aged 12-14 years old in South Africa. Secondly, to identify the demographic, socioeconomic and subjective norm characteristics associated with HIV knowledge among younger adolescents aged 12-14 years old in South Africa. 3.Methodology This study utilised secondary data acquired from the fifth South African National HIV, Behaviour and Health Survey of 2017 – this was the latest survey available data was analysed using STATA version 14. The South Africa National HIV Prevalence, Incidence, Behaviour and Communication Survey (SABSSM) is a national population-based survey conducted for surveillance of the HIV epidemic in South Africa. The sample for the study was younger adolescents aged 12-14 years old. The weighted sample of 927 861 was selected and used for analyses. The dependent variable in this study was HIV knowledge, defined as having accurate knowledge of all HIV-related questions from the survey. Eight questions assessing HIV and AIDS knowledge, perceptions, and stigma were used. Adolescents were asked about the curability of AIDS, reducing HIV risk by having fewer sexual partners, whether a healthy- looking person can have HIV, mother-to-child transmission, risk reduction by monogamy with an uninfected partner, HIV transmission through shared food, condom use, and male circumcision reducing HIV risk. The original response options were 'yes', 'no', and 'don't know', with 'don't know' responses excluded to ensure that the data accurately reflected the participants knowledge on HIV and AIDS. The dependent variable had three categories: low HIV knowledge (1-3 out of the eight questions answered correctly), average HIV knowledge (4-5 out of the eight questions answered correctly), and comprehensive HIV knowledge (6-8 questions answered correctly). A Multinomial Logistic Regression model was employed to analyse HIV knowledge. The data analysis was done in three phases. The first phase included descriptive analyses of utilised in the study through a ranked frequency and percentage distribution table and sex ratio which was used to explore the HIV knowledge levels based on sex. The second stage included Pearson’s chi-square test which were to measure the associations between the demographic, socioeconomic and subjective norms. The third stage included an unadjusted (bivariate) and adjusted (multivariate) Multinomial Logistic Regression which was employed to examine the demographic, socioeconomic and subjective norms associated with HIV knowledge among younger adolescents aged 12-14 years old in South Africa. 4.Results Less than half of younger adolescents (47.0%) had comprehensive HIV knowledge. The relative risk ratio shown in the multivariate Multinomial Logistic Regression model showed that the respondent’s age, sex, race, place of residence, province, grade, orphanhood status and subjective norms are significant predictors of HIV knowledge among younger adolescents aged 12-14 years old in South Africa. These associations indicated that non-African female adolescents are less likely to possess HIV knowledge compared to Black male adolescents, but generally, female adolescents have a slightly higher relative risk of possessing comprehensive HIV knowledge compared to their male counterparts (1.01, P<0.05; CI=0.99-1.03). Adolescents residing in rural areas have higher relative risks of possessing average and comprehensive HIV knowledge compared to those in urban areas, with relative risks increasing by 1.52 (P<0.05; CI=1.48-1.52) and 2.18 (P<0.05; CI=2.13-2.24), respectively. Additionally, willingness to share food with someone who has HIV/AIDS shows no significant difference in the relative risk of having average or comprehensive HIV knowledge (RRR:0.641; P<0.05; CI=0.62-0.65), while willingness to play with someone who has HIV/AIDS decreases the relative risks of having average and comprehensive HIV knowledge by factors of 0.32 (P<0.05; CI=0.32-0.33) and 0.13 (P<0.05; CI=0.12-0.13), respectively. Furthermore, adolescents uncomfortable discussing HIV/AIDS with at least one family member have decreased relative risks of possessing average and comprehensive HIV knowledge by factors of 0.27 (P<0.05; CI=0.27-0.28) and 0.30 (P<0.05; CI=0.29-0.30), respectively. These results highlight the importance of demographic and social factors in understanding HIV knowledge among young adolescents in South Africa. 5.Conclusion Despite significant efforts by the South African government to integrate HIV education into the national school curriculum and collaborate with NGOs and civil society groups, adolescents aged 12-14 still lack comprehensive HIV knowledge. Understanding HIV early plays a vital role in reducing stigma and discrimination associated with HIV/AIDS, fostering a supportive and inclusive atmosphere. It also promotes critical thinking among adolescents, empowering them to question myths and misunderstandings about the disease, thereby encouraging healthier behaviours and attitudes. The hypothesis for this research was that there is no association between demographic, socioeconomic and subjective norm characteristics and HIV knowledge among younger adolescents in South Africa. The multinomial logistic regression showed significant results. Therefore, the null hypothesis was rejected. Post the completion of the National Youth HIV Prevention Strategy (2022-205), it will become mandatory for the government to evaluate and refine the policy framework to include those under 15 years. Including those aged 12-14 years old will be crucial for fostering a generation equipped to safeguard their sexual health and make informed choices, thereby perpetuating the efficacy and relevance of HIV prevention efforts within the broader national agendaItem Role of novel biomarkers in predicting chronic kidney disease progression among black patients attending a tertiary hospital in Johannesburg, South Africa(University of the Witwatersrand, Johannesburg, 2023) Meremo, Alfred Jackson; Naicker, Saraladevi; Duarte, Raquel; Paget, Graham; Dickens, CarolineBackground: Chronic kidney disease (CKD) is a leading health issue and its magnitude has been increasing globally; where the developing countries are the most affected and they are the least equipped to deal with its associated consequences. Chronic kidney disease can rapidly and quietly progress to late CKD stages in impoverished environments. Early recognition of patients who are likely to develop end-stage kidney disease (ESKD) is important. Methodology: A prospective longitudinal study was conducted on CKD patients of black ethnicity attending at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) renal outpatient clinic in South Africa, as from September 2019 to March 2022. Patients provided blood and urine samples for investigations in the laboratory at study enrolment (0) and at the 24 months follow up. The concentrations of the transforming growth factor isoforms [(TGF)-β1, TGF-β2 and TGF-β3) were determined in serum and urine at baseline using the Human TGF-β duoset ELISA. Data were descriptively and inferentially processed by the REDcap and analyzed using STATA version 17 and multivariable logistic regression analysis was applied to find out the predictors of CKD progression. Results: A total of 312 patients were recruited into the study; the median age was 58 (IQR 46 -67) years and 162 (51.9 %) were male. Hypertension was present in majority (96.7 %) of the patients. Diabetes mellitus was present in 38.7 % of patients and 38.1 % of the study patients had both hypertension and diabetes mellitus. A total of 297 (95.2%) patients completed the study. Death was reported in 5 (1.6%) patients and 10 (3.2%) of patients were lost to follow up. The prevalence of CKD progression was 49.5%, 33% had CKD remission and 17.5% had CKD regression while the prevalence of CKD progression by change in uPCR > 30% was 51.9%. Almost half (47.8 %) had a sustained decline in eGFR of > 4 ml/min/1.73 m2 /year or more, 35.0% of the patients moved to a more severe stage of CKD and 19.9% had more than 30% 6 decline in eGFR in two years. For patients with CKD progression, 54.9% patients were men and at baseline, their median age was 59 (46 - 67) years, urine protein creatinine ratio (uPCR) increased at 0.039 (0.015-0.085) g/mmol, eGFR was 37 (32 -51) mL/min/1.73 m2; the median serum TGF-β1 was 21210 (15915 – 25745) ng/L and the median urine TGF-β3 was 17.5 (5.4 –76.2) ng/L. For those who had CKD progression, hypertension was present in the majority (95.2%) of the patients. Diabetes mellitus was present in 59 (40.1%) patients and 58 (39.5%) patients had both hypertension and diabetes mellitus; 48.3% had severely increased proteinuria, 45.6% patients had anaemia, 34.0% had hyperuricemia and 17.7% had hypocalcaemia at baseline. For those patients with CKD progression vs those without CKD progression, the baseline median serum TGF-β1 was 21210 (15915 – 25745) ng/L vs 24200 (17570 – 29560) ng/L, the baseline median urine TGF-β3 was 17.5 (5.4 – 76.2) ng/L vs 2.8 (1.8 – 15.3) ng/L; however, baseline serum and urine TGF-β isoforms did not predict progression of CKD on univariate and multivariable analyses. Regarding use of medications among patients with CKD progression, calcium channel blockers (amlodipine) were used by majority (85.2 %) of the patients. Diuretics were used by 63.4% of the patients and 31.7 % of the patients were using insulin. Variables associated with CKD progression after multivariable logistic regression analysis were moderately elevated proteinuria (OR 2.1, 95% CI (1.1 – 3.9), P= 0.019), severely elevated proteinuria (OR 6.1, 95 % CI (3.2 – 11.6), P = 0.001), hyponatraemia (OR 4.5, 95% CI 1.8 - 23.6, P= 0.042), hypocalcaemia (OR 3.8, 95 % CI 1.0 - 14.8, P = 0.047), anaemia (OR 2.1, 95% CI 1.0 - 4.3, P= 0.048), elevated HbA1c (OR 1.8, 95 % CI 1.2 - 2.8, P = 0.007), diabetes mellitus (OR 1.8, 95 % CI 1.9 - 3.6, P = 0.047), current smoking (OR 2.8, 95 % CI 1.9 - 8.6, P = 0.049), medications which were calcium channel blockers (OR 2.07, 95 % CI 1.04 – 4.12, P = 0.038), diuretics (OR 2.35, 95 % CI 1.37 – 4.00, P = 0.002), insulin (OR 1.96, 95 % CI 1.01 – 3.84, P = 0.048) and baseline serum calcium levels (OR 0.06, 95 % CI 0.01 -0.64, P = 0.019). An increase in uPCR > 30% at two years identified most patients with CKD progression; clinicians and nephrologists should utilize change in uPCR > 30% at two years to identify those patients with CKD who are likely to progress more rapidly, who require closer surveillance and monitoring with emphasis on slowing or stopping progression of the CKD. Conclusion: Our study has demonstrated a higher prevalence of CKD progression in a prospective longitudinal study among black patients than that reported in previous studies. CKD progression was associated with current smoking, hyponatremia, hypocalcemia, anaemia, elevated HbA1c, diabetes mellitus, and proteinuria. While patients with CKD progression had lower baseline concentrations of serum TGF-β1 and increased baseline urinary TGF-β3 concentrations, baseline serum and urine TGF-β isoforms did not predict progression of CKD. The roles of the various serum and urine TGF-β isoforms in CKD progression at baseline are still unclear and highlight the importance of further studies to determine their isoform specific effects.Item The social contexts of childhood malnutrition in South Africa(University of the Witwatersrand, Johannesburg, 2024) Sello, Matshidiso Valeria; Odimegwu, Clifford; Adedini, SundayBackground: Childhood malnutrition is a major public health challenge of global importance. It may result from either excessive or deficient nutrients. Despite investments and several efforts made by the South African government and civil society organizations to improve child health, the prevalence of childhood malnutrition remains high in South Africa. South Africa is still lagging in in achieving the sustainable development goals 1-3 (i.e., 1- no poverty, 2 – zero hunger and 3 –good health and wellbeing). This is because the indicators of childhood malnutrition are significantly higher with one in four children being stunted, 13% overweight, and 7.5% underweight. These figures highlight a troubling trend that is echoed in many other African nations, where malnutrition rates are similarly concerning. For instance, while countries like Nigeria and Ethiopia face severe challenges with stunting rates exceeding 30%, South Africa’s rates are comparatively lower but still indicative of a significant public health challenge. In contrast, developed nations such as the United States report much lower stunting rates—around 3.4%—and face different nutritional issues, such as rising obesity rates among children. The current malnutrition status is worrisome in South Africa given that these conditions have not changed much in nearly three decades. Among other factors recognised as the leading causes of poor nutrition outcomes is food insecurity in households -defined as the lack of regular access to safe, sufficient, and nutritious foods, disrupted eating patterns and reduced food intakes. Despite South Africa being a net exporter of food, it is characterised by high poverty, reduced opportunities for higher education, employment challenges, environmental hazards, substandard housing, and health disparities, still have challenges in access to affordable safe nutritious foods. Furthermore, due to the complexity of childhood malnutrition, an integrated multisectoral approach among families, communities, and government systems is critical to ensuring positive child health and nutritional outcomes. Addressing poor nutritional outcomes among under-5 children requires policy-relevant evidence. While the literature shows that childhood malnutrition is a multifaceted issue influenced by poverty and poor socio-economic outcomes, evidence is sparse on how structural and environmental factors operating at different levels influence childhood malnutrition. Therefore, an understanding of social contexts of childhood malnutrition is required to improve children’s health outcomes in South Africa. Hence, this study examined the social context of childhood malnutrition in South Africa with a focus on individual child, 15 caregiver, and household-level characteristics. The study addressed five specific objectives: i) to determine the levels and patterns of childhood malnutrition in South Africa, (ii) to examine the individual child, caregiver, and household factors associated with childhood malnutrition in South Africa, (iii) to investigate the influence of food insecurity on childhood malnutrition, (iv) to explore the extent to which the socio-cultural and childcare practices of caregivers predispose under-5 children to malnutrition in selected low-income communities in South Africa, and (v) to investigate the role of a multi-sectorial approach in improving child nutritional outcomes in SA. This study was guided by the 2020 UNICEF conceptual Framework on Maternal and Child Nutrition as well as the Food and Nutrition Security Theory. Methods: This study adopted an explanatory sequential mixed methods design (i.e., analysis of quantitative data followed by qualitative data collection and analysis). The research methodology was broken into the quantitative and qualitative study. The quantitative study entailed analysing the quantitative secondary data from the 2017 South Africa National Income Dynamics Study (NIDS Wave 5). The NIDS data was nationally representative. The sample was weighted using post-stratified weights. Data of 2 966 children and their mothers were analysed. These children were selected on the basis that they had complete anthropometric measurements (height and weight measurements) and were suitable and selected for the investigation of childhood malnutrition (stunting, overweight, and underweight). We also conducted qualitative in-depth interviews with Early Childhood Development (ECD) practitioners to gain a deeper understanding of their experiences in childcare and perceptions of feeding practices. They were key informants since under-5 children spent a lot of time at ECD centres. Data were analysed at the univariate level to obtain descriptive statistics, and at the bivariate level using the chi-square test of association. At the multivariate level, multi-level binary logistic regression was employed, and odds ratios were reported. The multilevel analysis involved two levels – the individual level (child and mother characteristics) and the household-level characteristics. Data were analysed using Stata software (version 17). The selection of the independent variables was guided by the literature review and conceptual framework of the study. The second part of the study was qualitative and was collected between June and August 2022. Twenty in-depth interviews, and five focus group discussions with mothers of under-5 children, and five in-depth interviews with early childhood development practitioners (ECD practitioners) were conducted. Interviews were conducted using semi-structured questionnaires in selected low-income communities in urban 16 Gauteng (i.e., Thulani in Soweto), and in rural Limpopo (i.e., GaMasemola in Sekhukhune District). These communities were selected based on high poverty and unemployment rates, had substandard houses, insufficient infrastructure and environmental issues. The qualitative data provided deeper understanding about ethe quantitative findings and explored questions that were not available to the researcher in the NIDS dataset. The focus group discussions and key-in- depth interviews further provided a follow-up and an explanation of the quantitative findings. Thematic analysis was used to analyse qualitative data. Key findings from objective 1: In terms of descriptive findings, found that 22.16% of children were stunted, 16.40% were overweight, and 5.04% were underweight. The distribution of children among female and male children in the study population was almost the same. About 40% of the children had a low birth weight (<3 kg), 80.59% relied on the child support grant, and 67.22% were cared for at home during the day. Different patterns of malnutrition were observed. The highest percentage of children ages 12-23 months were stunted (33.43%) and overweight (32.69%), while the highest proportion of children ages 0-11 months and 48-59 months were underweight. Among children with a low birth weight of 1-2.9 kg, the highest percentage of stunting (30.07%) (p = 0.001, χ² = 71.2) and underweight (7.05%) (p = 0.026, χ² = 16.9) was observed. There was a relationship between access to medical aid, access to the child support grant, and childhood stunting (p < 0.05), while being cared for at home during the day was associated with stunting (24.98%) and overweight (18.99%) (p = 0.002, χ² = 36.3). Caregivers’ religion was associated with overweight (p = 0.007, χ² = 25.6) among under-5 children, while caregiver’s ethnicity (p = 0.024, χ² = 18.4) was associated with underweight. Key findings from objective 2: Female children had a lower likelihood (0.63 times) of being stunted compared to males. Children aged 12-23 months face a 60% higher risk of being overweight than those aged 0-11 months (AOR = 1.6). However, the risk of overweight declines steadily as age increases. Children aged 48-59 months are 83% less likely to be overweight compared to the youngest group of 0-11 months (AOR = 0.17). Children with a birthweight of 3 kg are 63% less likely to be underweight compared to those weighing 1-2 kg at birth (AOR = 0.37). Children attending crèches/day moms are 69% less likely to be underweight compared to those cared for at home (AOR = 0.31). Children cared for at home are 1.5 times more likely to be stunted (AOR=1.49) compared to children at a creche/day mom. Caregivers who were Nguni 17 had a 26% lower likelihood of having stunted children. Caregivers of other religions had 2 times higher likelihood of having overweight children compared to Christian caregivers (AOR=1.21). Middle-income households were associated with having overweight children (AOR=1.35) compared to low-income households. Children from structurally sound households had a 54% of high risk of being overweight compared to children from dilapidated household structures. The study found that a significant portion of the variation in child malnutrition (stunting, overweight, and underweight) occurred within communities. This is evident from the intraclass correlation of stunting (ICC) values from 27.9% to 30.2% variation, 34.3% to 38.2% overweight variation and 19.6% to 33,9% underweight variation within communities. The increase in ICC after adding additional variables suggest that these factors explain more of the variation within communities. Key findings from objective 3: The results showed that nearly 30% of the households were below the lower-bound food poverty line of R890 per person per month in South Africa, and just about half of the households did not always have enough available foods all the time. The qualitative findings show that the COVID-19 pandemic exacerbated the food insecurity during the COVID-19 lockdown, when many caregivers lost their income sources due to job losses. Food affordability and availability in the households became a major issue, forcing households to make hard decisions between deciding on foods with high nutrition that should be eaten against diverting financial resources and paying for other household expenses such as rent or electricity. Caregivers understood that they should be feeding their children nutritious foods but due to financial constraints, they were forced to give children the available but less nutritious foods in the households. Key findings from objective 4: Qualitative findings further showed that caregivers had various socio-cultural and childcare practices which influenced children’s nutritional and health outcomes. Socio-cultural practices that influenced childhood malnutrition included dietary choices – these were not necessarily affected by cultural beliefs, but they were rather influenced by the lack of income. Traditional beliefs on food- such as foods like eggs and dairy products such as milk or yoghurts were not given to girls. This was from a belief that this food would make girls more fertile and grow much faster. Traditional healing practices influence the dietary restrictions, limiting access to some nutritious foods, which are based on superstitions and lead to stigma. With regards to the childcare practices, there was also a lack of clarity by caregivers 18 on the duration of exclusive breastfeeding as well as the duration when the children should stop breastfeeding. Caregivers did not have adequate knowledge about when to resume weaning. Some caregivers highlighted that the last time they received nutrition knowledge was when their children were infants, and they had taken the children for vaccinations. Caregivers were not aware of how responsive caregiving such as child feeding frequency and portion sizes could improve children’s nutritional outcomes. Key findings from objective 5: From the qualitative interviews with early childhood development (ECD) practitioners, findings indicated a growing disintegration of childcare systems, including the family, health, and social systems, where a lack of parental support in nutrition programmes, a lack of support in health services and other social services when making referrals. Furthermore, various systems of care were working in silos in childcare service provision, resulting in children facing multiple adversities. Conclusions: The study demonstrated that individual-level child characteristics appear to exacerbate childhood malnutrition more than the mother and household-level characteristics. For example, the child level characteristics showed high significance, with age, sex, and child support grant, compared to the caregiver characteristics such as education, employment, and income. At the household level, variables such as household size and income did not show any significance. While this is the case, it does not necessarily mean that the mother and household-level characteristics were not important. This gap can be explained by the small sample, which can cause challenges of limited statistical power, making it harder to detect statistically significant differences. Furthermore, the qualitative assessment filled some gaps regarding these findings and gave an in-depth understanding on how the income disparities among caregivers and households result from high unemployment rates, highlighting the importance of socio-economic status and food security in child nutritional outcomes. From the ECD practitioners’ interviews, given the disintegration of childcare systems, the coordination and multisectoral collaboration of different sectors of care for children is urgently needed to improve children’s nutritional outcomes. Understanding the social context in which a child is brought up is important for the design of programmes and policies that will be effective in addressing this public health challenge. This understanding will enable efficient and effective service referral and service delivery to improve childhood nutrition in South Africa. This study highlights the need for a good 19 coordination of food, family, health, and social systems to ensure a positive childhood nutritional outcome.Item Depression Demographic Profiling of Young Adults in South Africa(University of the Witwatersrand, Johannesburg, 2024) Bambo, Matsidiso Princess; Hassem, TasneemIn young people aged 15 and 29 years, mental illnesses accounted for 23% of Years Lived with Disability (YLD) and among mental disorders, depressive disorders emerged as the second largest worldwide contributor to YLD at approximately 5.6%. In addition, one in every six individuals suffered from depression in South Africa. However, there is limited recent research about the demographic characteristics of South African emerging adults who may be vulnerable to depression. This research aimed to conduct demographic profiling of emerging adults (N=819) in South Africa who present with depressive symptoms. Additionally, using Pearson’s Product-Moment Correlation, T-test, and ANOVA, this cross- sectional research analysed secondary data from the Africa Long Life Study to determine relationships as well as statistical differences among demographic variables and depressive symptoms. Results indicated a low presence of depression in the sample. Significant relationships were found between depressive symptoms and demographic variables (socioeconomic status and religiosity). While no significant differences were found among language groups, a higher presence of depressive symptoms was found among females and those experiencing moderate to great financial difficulties. The findings emphasised the critical need for mental health policies and initiatives that promote prevention or early detection, prevention, and enhanced access to quality mental healthcare, particularly among vulnerable emerging adults like females and individuals who are economically disadvantaged. Mental health interventions should adopt comprehensive approaches that incorporate aspects of religiosity and spirituality to buffer against the presence of depressive symptoms among emerging adultsItem An analysis of the relationship between HIV-testing and cervical cancer screening uptake among females of reproductive age (15-49 years old) in South Africa(University of the Witwatersrand, Johannesburg, 2024) Madubye, Koketšo Tholo; Wet-Billings, Nicole DeBackground: Higher income countries (HIC) have threefold testing coverage over lower to middle income countries (LMIC). Cervical cancer is the 4th most prevalent cancer among females globally, and a key contributor to mortality in Southern Africa. In LMIC, including South Africa, only 9% of the eligible screening cohort had ever undergone cervical cancer screening. This study examined the gap in understanding the relationship between HIV testing behaviours and the uptake of cervical cancer screening. Methods: The study was conducted in South Africa, utilising the 2016 South African Demographic and Health Survey (SADHS), as a secondary data source. The sample size of this study was a weighted (n) distribution of 4,199 females. The study design is cross-sectional, the outcome variable of interest in this study was the uptake of cervical cancer screening and the predictor variable is HIV Testing. The data by SADHS (2016) was analysed through the three phases: univariate, bivariate and multivariate. At the bivariate level, contingency tables were employed, using the Pearson chi-square test of association which examined the strength of crude relationships between cervical cancer screening and the study of independent variables. In addition, a multivariate analysis through the employment of a binary logistic regression as the outcome of the study was categorised with ‘yes’ and ‘no’ binary responses. Results: The findings of this study indicated that 33% of females of reproductive age had ever undergone cervical cancer screening, while 62.5% responded affirmatively to having tested for HIV. Females who tested for HIV displayed a higher propensity to having undergone cervical cancer screening, 37.43% female respondents who tested for HIV had undergone screened for cervical cancer, as opposed to those who didn’t test, which only 10.19 % screened for cervical cancer. Conclusions: 37.43% female respondents who tested for HIV had undergone screened for cervical cancer. Among those who did not test for HIV, 10.19 % screened for cervical cancer. There is still much to be done to improve cervical cancer screening among females, while HIV testing remains high, cervical cancer screening is alarmingly low. The 2017 Cervical Cancer Prevention and Control Policy functions as a mediating apparatus, additional supplementations targeting females below the age of 30 remain a necessityItem Voiding cystourethrography in the renal pre-transplantation workup: an essential investigation?(University of the Witwatersrand, Johannesburg, 2022-10) Sofianos, Zelia; Rajkumar, Leisha; Lucas, SusanINTRODUCTION: Due to resource constraints in the South African public healthcare sector, patients with End-Stage Renal Disease (ESRD) are eligible for renal replacement therapy only if they are also found to be eligible for renal transplant. AIM: The aim of this study is to document Voiding Cystourethrogram (VCUG) findings in potential renal transplant candidates to assess the contribution of the VCUG as a standard investigation in the renal transplant workup. METHODS: Of the patients who underwent VCUG in Klerksdorp/Tshepong Hospital Complex (North West province, South Africa) from 1 January 2019 to 31 March 2020, 85 patients were included in the study and their VCUG findings retrospectively analysed. RESULTS: The mean age was 40.0 years (range 21-62 years), with males constituting 57.7% of patients and females 42.3%. Lower urinary tract abnormalities were identified in 24.7% of patients, some of whom had more than one abnormality. Of the total abnormalities, VUR (vesicoureteral reflux) accounted for 15.3%, bladder diverticula for 5.9%, urethral strictures for 3.5% and a significant post-void residual volume for 4.7%. No comorbidities were found to have a statistically significant association with the presence of VCUG abnormalities. CONCLUSIONS: To ensure that patients with End-Stage Renal Disease are adequately prepared for renal dialysis and potential renal transplant, and that their comorbidities and lower urinary tract are optimised should abnormalities be identified on VCUG, the VCUG remains an essential investigation in the renal transplant workup.Item Maternal death at Leratong Regional Hospital: a six-year retrospective review, South Africa(University of the Witwatersrand, Johannesburg, 2021-11) Motau, Tumelo Ngaka; Chauke, LawrenceBackground: The aim of the study was to systematically examine the main causes of maternal deaths and contributing factors at Leratong Regional Hospital in order to recommend strategies that can assist in reducing maternal mortality at this level of healthcare. Objectives: The objectives of the study were to: determine the institutional maternal mortality rate at Leratong Regional Hospital between 2012 to 2017, compare the trend (year on year) in the iMMR over the study period, describe the profile of women who died during the period under study, describe the clinical and surgical management of the women who died, and to determine the leading causes of maternal deaths, contributing factors and avoidable factors. Methods: A hospital based retrospective study based on patient clinical records at Leratong hospital. It included all the maternal deaths that occurred at Leratong Regional Hospital during the six-year study period (2012-2017). Results: There was a total of 78 maternal deaths with 32441 live births giving the MMR of 240 per 100 000 live births. However only 74 files could be analysed. The results showed that there was a rise in the maternal mortality rate over a six years period. The majority (70, 94.5%) of the women who died were African, aged between 20-35 years (56, 76%), multigravida (54,73%) with a parity of three or more (23, 31%). Obstetric haemorrhage was the leading cause of maternal death particularly postpartum haemorrhage (11.14%) followed by non-pregnancy related infections, sepsis and eclampsia. Conclusion: Maternal mortality has decreased according to recent confidential enquiry into maternal death in South Africa (2017-2019) However our study did not demonstrate a decline but rather an increase in the maternal mortality rate at Leratong. It showed that most of the maternal deaths were avoidable and the need for urgent interventions in terms of education, improving access to health care facilities, intensifying health care worker skills training and better transport systems between health care facilities is important.Item Adherence to the Standard Treatment Guidelines in managing patients with hypertension at Chiawelo Community Health Centre, Gauteng, South Africa(University of the Witwatersrand, Johannesburg, 2022-04) Dawduth, Nikkeeta; Torlutter, MicheleBackground: Hypertension is a highly prevalent chronic disease, causing significant morbidity and mortality and is poorly managed and controlled in primary care, with only 24.5 to 56% of patients being controlled. Aim: The aim of the study was to determine health care worker adherence to the Standard Treatment Guidelines in managing hypertensive patients in primary care. Methods: The study was conducted at Chiawelo Community Practice Johannesburg. A retrospective file review was done on 261 hypertensive patients and information extracted to determine whether health care workers performed correct baseline tests at diagnosis; correct investigations were done on ongoing basis; lifestyle modification was addressed; and correct pharmacological therapy was prescribed and titrated. Data analysis included descriptive statistics and bivariate analysis. Results: A total of 77% of participants were female and 23% were male of which 80.5% participants had co-morbidities. Patients were treated by a doctor in 97% of cases; 84.3% by clinical associate, and 0.6% by a nurse only over time. Baseline findings recorded in the file at diagnosis were: weight 65.9%, height 73.2%, potassium 32.2%, BMI 50.2%, abdominal circumference 51.7%, and urine dipsticks 47.9%. Vitals and investigations recorded in the file: BP 99.6%, weight 19.5%, blood glucose 86.6%, creatinine 95.4%, eGFR 94.3% and urine protein 3.4%. Lifestyle modification was recorded for 23.7% and medication adherence was checked and recorded for 36.4% of patients. The correct antihypertensive medications were prescribed in 96.5% of patients but titrated correctly in only 73.5% of patients. 52.8% of patients were controlled on treatment. Conclusion: Adherence to guidelines by health care workers was suboptimal and several aspects of care warrants quality improvement processes.Item COVID-19 and health care worker exposure at Chris Hani Baragwanath Academic Hospital(University of the Witwatersrand, Johannesburg, 2021-12-05) Glatt, Sara Chaya; Menezes, Colin; Winchow, Lai ling; Tsitsi, MerikaBackground: Health care workers (HCWs) are at an increased risk of acquiring coronavirus disease 2019 (COVID-19). Appropriate risk assessments and testing are essential to reduce transmission and avoid workforce depletion. Objective: Investigate the risk of COVID-19 infection among HCWs at Chris Hani Baragwanath Academic Hospital who fulfil the Person Under Investigation (PUI) case definition or had exposure to a confirmed COVID-19 contact. Methods: A retrospective review of HCW records was conducted over a two month period. Data collected included demographics, exposure type, risk level, and COVID-19 test result. Frequency distribution tables, bivariate analyses and univariate and multivariate analyses were conducted. Results: Among the 1111 HCWs reviewed, 643 were tested with 35.6% positive results. PUI’s accounted for 62.4% of positive cases. Symptomatic HCWs with no known contact were at a greater risk of infection than those with a patient exposure (p=0.000). Risk of testing positive was higher after a patient exposure (p=0.000) compared to a co-worker contact. Conclusion: There is a higher positivity rate among HCWs than the general population. The presence of symptoms warrants testing. Nosocomial transmission was derived from patient more than co-worker contacts.