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Inability of methylene blue to protect the enamel organ against vitamin E deficiency

(1954) Irving, J T

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Sensitivity of different tissues to vitamin A deficiency and to the prophylactic action of the vitamin

(1954) Irving, J. T.; Richards, M. B.

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The relation between the action of vitamin E and protein in the body, and the influence of various fish-liver oils in the diet upon vitamin E activity in vivo

(1955) Irving, J. T.; Budtz-Olsen, O. E.

The experiments reported here were undertaken primarily to investigate further the histological changes occurring in the enamel organ of the rat’s incisor tooth during vitamin E deficiency. These changes were originally described by Irving (1942) and have been confirmed in general by Granados, Mason & Dam (1945, 1946) and by Pindborg (7950, 1952). It was, however, found by the present writers, usinga diet based on that of Gillman, Gilbert, Gillman & Spence (1952), that extreme changes in the enamel organ, avertable by vitamin E, could be produced in 21 days or less, whereas the changes described by the other authors took much longer to develop and were less extensive. In an attempt to determine further the effects of other dietary factors upon the enamel organ, certain additional findings seemed to be of significance. The present paper is concerned chiefly with these, and an account of the histological aspect is being prepared for publication. In particular it was found that the vitamin content of the oil containing highly unsaturated fatty acids was of importance and also that the actions of protein and vitamin E, which superficially appeared similar, differed in certain fundamental respects