A randomised study to compare radical concurrent chemoradiation against radical radiotherapy, as a treatment of cancer of the cervix in HIV infected patients

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dc.contributor.author Msadabwe, Susan Citonje
dc.date.accessioned 2009-11-24T13:49:53Z
dc.date.available 2009-11-24T13:49:53Z
dc.date.issued 2009-11-24T13:49:53Z
dc.identifier.uri http://hdl.handle.net/10539/7468
dc.description M.Med., Faculty of Health Sciences, University of the Witwatersrand, 2009 en_US
dc.description.abstract Objectives Cancer of the cervix is one of the commonest cancers in South African females. Up to 30% of patients are HIV positive. The addition of chemotherapy to radiotherapy has been shown to significantly improve local control and survival and concurrent chemoradiation is the standard treatment for locally advanced cancer of the cervix. There is very limited literature available concerning the tolerance and efficacy of this treatment in HIV positive patients. This study aims to assess the acute toxicity of combined modality treatment in these patients. This study is part of a multicenter International Atomic Energy Agency sponsored study. Materials and methods Patients with FIGO stage IB2 to IIIB (without hydronephrosis) cervical cancer and who are HIV positive, were randomized to receive radiotherapy alone or chemo-radiation. All patients received 46 Gy in 23 fractions external beam radiation and high-dose-ratei brachytherapy 8 Gy x 3 fractions. Chemotherapy consisted of bolus Cisplatin 30mg/m2 weekly given concurrently with the radiotherapy. Acute treatment toxicity was documented weekly during treatment. Results 64 patients were recruited to the study. 31 patients were randomized to the chemoradiation arm and 33 patients to the radiation alone arm. Of the 64 patients recruited to the study, 6 in the chemoradiation arm and 5 in the radiation only arm did not receive any treatment and were therefore not evaluated. Stage IIB was the most common stage. The mean CD4 count was 410 in the chemoradiation arm vs. 358.4 in the radiation only arm at randomization. Only 6 patients were on antiretroviral therapy at start of treatment, 3 in each arm. The number of chemotherapy cycles received by patients in the chemoradiation arm ranged between 0 and 5 cycles. A total of 96 chemotherapy cycles were administered, with a median of 4 cycles per patient. Overall, at least 76% of patients received at least 4 cycles of chemotherapy. The full five intended courses of cisplatin were administered in 10 (40%) patients. Chemotherapy was not administered most commonly due to toxicity (renal, leucopaenia), other reasons being logistical and non compliance. The principle major adverse effects observed were leucopaenia and cutaneous reactions. en_US
dc.language.iso en en_US
dc.subject cervical cancer en_US
dc.subject HIV en_US
dc.subject chemotherapy en_US
dc.subject radiotherapy en_US
dc.subject radiation therapy en_US
dc.title A randomised study to compare radical concurrent chemoradiation against radical radiotherapy, as a treatment of cancer of the cervix in HIV infected patients en_US
dc.type Thesis en_US

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