A new model of population dynamics of HIV-1 in vivo

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dc.contributor.author Cawse, Kerry-Anne
dc.date.accessioned 2009-09-08T09:00:44Z
dc.date.available 2009-09-08T09:00:44Z
dc.date.issued 2009-09-08T09:00:44Z
dc.identifier.uri http://hdl.handle.net/10539/7206
dc.description.abstract Using a simple model of HIV-1 viral load and infected CD4+ count, with easily measurable coe cients, valid on time scales of approximately a month, we nd that HIV-1 is understood by sequential outburst of viral populations with delay between populations. AIDS is characterised by shorter delays between viral populations and HAART is characterised by longer delays between viral populations, as evidenced in observed viral blips. Infected CD4+ dynamics is understood by sequential outburst with overlap of CD4+ populations. We argue that viral load and CD4+ counts must be in phase and present a model in di erential equations that supports this conclusion and is consistent with decay rates discovered by the outburst model. en_US
dc.language.iso en en_US
dc.title A new model of population dynamics of HIV-1 in vivo en_US
dc.type Thesis en_US

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