Molecular characterisation of the peripheral Benzodiazepine receptor in various human cancer tissues

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dc.contributor.author Bhoola, Nimisha Harshadrai.
dc.date.accessioned 2008-03-07T08:41:53Z
dc.date.available 2008-03-07T08:41:53Z
dc.date.issued 2008-03-07T08:41:53Z
dc.identifier.uri http://hdl.handle.net/10539/4584
dc.description.abstract ABSTRACT Background: The Peripheral Benzodiazepine Receptor (PBR) can be classified as a distinct receptor from the central benzodiazepine receptor. The PBR gene has been located to chromosome 22q13.31 in humans and has been found to consist of four exons, with the first and half of the fourth exon being untranslated to form the PBR protein. PBR is involved in numerous biological conditions including the regulation of cellular proliferation and apoptosis, steroidogenesis, heme biosynthesis, anion and porphyrin transport and mitochondrial functions such as oxidative phosphorylation and translocation of cholesterol from the outer to the inner mitochondrial membrane. Recent studies showed that the expression of PBR correlated with tumour malignancy and patient survival. Aim: The objectives of this research were to determine the expression pattern and level of PBR mRNA in various types of human normal and cancer tissues and to isolate the PBR protein. en
dc.format.extent 45388055 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.subject Peripheral Benzodiazepine Receptor en
dc.subject cancer en
dc.title Molecular characterisation of the peripheral Benzodiazepine receptor in various human cancer tissues en
dc.type Thesis en


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