The ability of the Generalised AMBER Force Field (GAFF) to model the structure of bisphosphonate ligands, C(R1)(R2)(PO3 2-)2, important compounds in the treatment of bone cancer, by molecular mechanics methods is ...

Child abuse is rife and on the increase in South Africa. The review of five theories of child abuse shows that each theory is unitary, limited and isolated and proposes an incomplete understanding of and solution to child ...

The synthesis of nitrogen containing ring systems has been one of the interests of this research group at the University of the Witwatersrand for a long time. These systems form part of a group of compounds called ...

A passive investment management model was developed via a critical literature review of portfolio methodologies. This model was developed based on the fundamental models originated by both Markowitz and Sharpe. The passive ...

Learner’s processing styles may play a vital role in their approach to learning, more specifically; the ability to make inferences plays an important role in all areas of language and learning and may contribute to ...

A mathematical model is used to describe the pyrolysis of South African coal, biomass and coal-biomass blends. The model makes use of a modified form of the Distributed Activation Energy Model (DAEM) to predict and ...

Background: The t(8;14) translocation in Burkitt’s lymphoma (BL) was the first non-random cytogenetic lesion to be described in lymphoproliferative disorders. This lesion occurs in 75-85% of all BL cases. However, ...

Retinoblastoma binding protein 6 (RBBP6) is a nuclear protein, previously implicated in the regulation of cell cycle and apoptosis. It is a multi-domain protein containing a Zinc finger, a RING finger, an Rb binding domain, ...

Mental retardation (MR) is estimated to affect ~2-3% of the general population and may result from genetic causes and/or environmental causes. X-linked mental retardation (XLMR) is a heterogeneous group of disorders with ...

The molecular mechanisms of glycopeptide resistance in two Gram-positive clinical isolates, Bacillus lentus RSA1208 and Paenibacillus thiaminolyticus RSA1221 were investigated. The glycopeptide resistance genotypes were ...