Impact of dexmedetomidine on postoperative biomarkers,length of hospitalisation and mortality in patients undergoing coronary artery bypass graft surgery
Date
2019
Authors
Motshabi, Palesa Mamoseki Violet
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Abstract
Coronary artery bypass graft surgery, a surgical procedure performed to alleviate the
symptoms of ischaemic heart disease and improve prognosis on cardiopulmonary bypass,
is beneficial in patients with ischaemic heart disease, however it is not without deleterious
adverse clinical events and mortality due to its associated inflammatory and stress
response. Dexmedetomidine, an a–2 adrenergic agonist, is a promising drug with a
potential towards myocardial protection due to its favourable pharmacological profile.
This study investigated the impact of dexmedetomidine compared to placebo on high
sensitivity troponin in patients undergoing coronary artery bypass graft surgery on
cardiopulmonary artery bypass in a randomised controlled trial. Secondary endpoints
included mortality and the length of hospitalization. Subsequently, a systematic review
and meta-analysis of randomised controlled trials on the effects of dexmedetomidine on
conventional troponin (cTn) compared to control was conducted.
Description
A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in
fulfilment of the requirements for the degree of Doctor of Philosophy,
Johannesburg 2019
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Citation
Motshabi, Palesa Mamoseki Violet, Impact of dexmedetomidine on postoperative biomarkers, length of hospitalization and mortality in patients undergoing coronary artery bypass graft surgery, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/29859>