Reversible phosphorylation of proteins in proliferating and differentiating cells : cyclic variations and the effect of growth regulators / Gracinda Maria Nunes Ferreira.
Date
1994
Authors
Ferreira, Gracinda Maria Nunes
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Abstract
Living cells are highly auto-dynamic entities which
means that the underlying biochemistry is equally
dynamic, a reality which is ignored by most researchers.
Theoretical studies indicate that such a state must be
due to the existence of oscillatory variations in the
levels and activities of key components in the cell. In
this study, the dynamic behaviour of four major,
interrelated areas of cell biochemistry
(phosphorylation, dephosphorylation, the terminal
reaction of glycolysis and the amount of soluble
protein) were examined and all systems found to
oscillate in murine erythroleukaemic cells (MEL) and,
where examined, also in the human HL-60 leukaemic cell
line. (Abbreviation abstract)
Description
A Dissertation Submitted to the Faculty of SCience
University of the Witwatersrand, Johannesburg
In fulfilment of the requirements
for the Degree of Doctor of Philosophy
Keywords
Protein kinases., Phosphorylation., Growth regulators