The effect of novel compounds on cell survival and apoptosis in colon cancer cell lines
Date
2013
Authors
Dahan-Farkas, Nurit
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Abstract
Colon cancer is the third most common cancer worldwide and the second most common in
the western world. More than 40 % of colon cancer sufferers develop metastases and
chemotherapy is often used alone or in combination with radiotherapy as adjunctive therapy
for the advanced disease. A major effort has been made in the past decade to develop anticancer
agents through both empiric screening and rational design of new compounds. These
attempts are made to improve the survival rate, reduce the severe adverse effects associated
with existing cancer chemotherapeutic agents as well as to reduce the development of drug
resistance. In the present study, two colon cancer cell lines were exposed to novel
imidazo[1,2-a]pyridines and novel nucleoside analogues, aiming to investigate the cytotoxic
efficacy on the cells, the mode of cell death, and to explore the pathways by which cell death
was induced.
Description
A dissertation submitted to the Faculty of Health Sciences, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree
of Masters of Science in Medicine (Pharmacology)
Johannesburg, 2013