Browsing ETD Collection by Title

Now showing items 3192-3211 of 5308

Molecular and epidemiological characterization of multidrug-resistant Mycobacterium tuberculosis isolates in Johannesburg, South Africa

Mlambo, Charmaine Khudzie (2012-01-10)

South Africa has a heavy burden of tuberculosis (TB) which is exacerbated by the concurrent epidemic of HIV. Molecular techniques have been used in most developed countries to investigate the dynamics of the TB epidemic, ...
Molecular aspects of X-linked mental retardation loci

Essop, Fahmida Bibi (2010-10-26)

Mental retardation (MR) is estimated to affect ~2-3% of the general population and may result from genetic causes and/or environmental causes. X-linked mental retardation (XLMR) is a heterogeneous group of disorders with ...
The molecular basis of Gaucher Disease in black South Africans

Arndt, Silke (2012-01-17)

Gaucher Disease (GD) is the most common recessively inherited lysosomal storage disorder. The clinical symptoms result from non-functional β- glucocerebrosidase (βGC), an important enzyme in the metabolism of glycosph ...
The molecular basis of glycopeptide Resistence in two Clinical Isolates: Bacillus Lentus RSA1208 and Paenibacillus Thiaminolyticus RSA 1221

Moodley, Arshnee (2006-10-25)

The molecular mechanisms of glycopeptide resistance in two Gram-positive clinical isolates, Bacillus lentus RSA1208 and Paenibacillus thiaminolyticus RSA1221 were investigated. The glycopeptide resistance genotypes were ...
Molecular characterisation and immunological analysis of clinical and environmental isolates of Mycobacterium kansasii from South African gold mines

Kwenda, Geoffrey (2011-03-31)

The South African gold-mining workforce has an unusually high incidence of Mycobacterium kansasii disease, yet little is known about the possible sources of M. kansasii infection, genetic diversity and the basis for this ...
MOLECULAR CHARACTERISATION OF HEPATITIS B VIRUS VACCINE ESCAPE MUTANTS IN SOUTH AFRICA

Crowther, Penny (2006-11-17)

Since the introduction of vaccination against hepatitis B virus (HBV) infection in South Africa, at least one case of infection despite vaccination has occurred. The purpose of this study was to determine whether this ...
Molecular characterisation of methicillin-resistant Staphylococcus aureus (MRSA) from South Africa

Oosthuysen, Wilhelm Frederick (2008-06-03)

ABSTRACT Few antibiotics are left that are effective against methicillin-resistant Staphylococcus aureus (MRSA) and even strains resistant to these agents have been isolated. Previous studies have identified five distinct ...
Molecular characterisation of Neisseria meningitidis serogroup B isolates in South Africa, 2002- 2006

Moodley, Chivonne (2011-10-17)

Despite being a fulminant pathogen, Neisseria meningitidis (meningococcus) is part of the commensal flora of the human nasopharynx. Globally, five meningococcal serogroups (A, B, C, Y and W135) cause the majority of ...
MOLECULAR CHARACTERISATION OF THE EXTRACELLULAR MATRIX PROTEIN 1 GENE IN LIPOID PROTEINOSIS IN SOUTH AFRICA

van Hougenhouck-Tulleken, George; Wesley (2006-11-20)

Lipoid proteinosis (LP) (OMIM 247100) is a rare autosomal recessive disorder that is caused by mutations within the extracellular matrix protein 1 gene (ECM1). The ECM1 gene has been shown to play a role in angiogenesis ...
Molecular characterisation of the Her2-Top2A amplicon in breast cancer

Herd, Olivia Jayne (2010-09-17)

The HER2 gene is amplified in 20-30% of breast cancers, a common cancer amongst South African women. HER2 amplification is associated with a poor prognosis and predicts response to treatments such as Herceptin. The gold ...
Molecular characterisation of the peripheral Benzodiazepine receptor in various human cancer tissues

Bhoola, Nimisha H. (2008-03-07)

ABSTRACT Background: The Peripheral Benzodiazepine Receptor (PBR) can be classified as a distinct receptor from the central benzodiazepine receptor. The PBR gene has been located to chromosome 22q13.31 in humans and has ...
The molecular characterisation, strain selection and induction of lipid synthesis in a suitable marine microalgal species for potential biodiesel production

Nambiar, Shari (2011-03-30)

The demand for alternative energy has increased exponentially and algal-based biofuels are viewed as a viable alternative. This study examined the lipid producing capability of Isochrysis and the role of phosphorus depletion ...
Molecular characterization of multidrug-resistant Salmonella Isangi in hospitalized patients

Kruger, Tersia (2008-08-19)

ABSTRACT Extended-spectrum beta-lactamase (ESBL)-producing Salmonella enterica serotype Isangi has emerged as a common Salmonella serotype affecting mainly children in hospitals throughout South Africa. Between 2000 and ...
Molecular characterization of unique hepatitis c viral genotypes in South Africa

Prabdial-Sing, Nishi (2012-01-17)

Hepatitis C is a notifiable disease in South Africa (SA), but there is a lack of surveillance and reporting systems. The availability of routine, reliable and validated methods of hepatitis C virus (HCV) detection and ...
Molecular detection of atypical bacteria and viruses linked to community-acquired pneumonia

Gumede, Nomathemba Michell (2009-09-22)

Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. Knowledge of the predominant agents associated with CAP locally is essential, as it represents the basis for empiric antibiotic ...
Molecular epidemiology and clinical characteristics of the human metapneumovirus in South Africa

Ludewick, Herbert Patrick (2008-03-19)

IV. ABSTRACT The human metapneumovirus is a novel paramyxovirus associated with acute respiratory infections in children, adults, elderly and immunocompromised individuals. It has a worldwide distribution and the prevalence ...
Molecular epidemiology and mechanism of resistance of invasive quinolone-resistant South African isolates of Salmonella enterica, 2004-2006

Govender, Nevashan (2009-09-11)

The molecular epidemiology and mechanism of quinolone resistance of South African human isolates of Salmonella Typhi for the period 2003-2007, Salmonella Enteritidis, Salmonella Isangi and Salmonella Typhimurium for the ...
Molecular epidemiology of invasive isolates of Salmonella enterica serovar Typhimurium in Gauteng, South Africa, 2006-2008

Dwarika, Sarika (2009-09-02)

The clonality of 840 invasive human Salmonella enterica serotype Typhimurium isolates isolated in Gauteng Province during January 2006 to May 2008 was investigated. PFGE analysis revealed 38 clusters: three (clusters 3, ...
Molecular epidemiology of South African serotype 3 and serotype 19A pneumococcal isolates

Mothibeli, Kedibone Maria (2008-05-26)

The clonality of a random sample of 102 invasive pneumococcal serotype 3 strains isolated from Gauteng Province during January 2000 to December 2003 was investigated. Pulsed-field gel electrophoresis (PFGE) and multilocus ...
Molecular evaluation of ribosomal protein L9 and lipoic acid synthetase genes and in lung and apoptosis

Mphahlele, Raesibe Paulinah (2012-09-05)

Background: A human ribosomal protein L9 (RPL9) encodes a protein that is a component of the 60S subunit. RPL9 is located on chromosome 4p14 and is approximately 5.5 kb in length and contains 8 exons. The message for human ...

Now showing items 3192-3211 of 5308

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